Differential Role of β1C and β1AIntegrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways
Fornaro M, Steger C, Bennett A, Wu J, Languino L. Differential Role of β1C and β1AIntegrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways. Molecular Biology Of The Cell 2000, 11: 2235-2249. PMID: 10888665, PMCID: PMC14916, DOI: 10.1091/mbc.11.7.2235.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCHO CellsCricetinaeCytoplasmEnzyme ActivationFibronectinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene ExpressionHumansIntegrin beta1IntegrinsMitogen-Activated Protein Kinase 1PhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRabbitsRas ProteinsSignal TransductionConceptsStable cell linesMAP kinase pathwayKinase pathwayRas activationERK2 activationRas/MAP kinase pathwayCell proliferationProtein kinase B/Akt activitySurvival signalsProtein kinase B/AktRas/mitogen-activated protein kinase pathwayExtracellular signal-regulated kinase 2 activationCell linesProtein kinase B/Akt phosphorylationMitogen-activated protein kinase pathwayFocal adhesion kinase phosphorylationUnique signaling mechanismVariant cytoplasmic domainKinase 2 activationFocal adhesion kinaseProtein kinase pathwayModulates cell proliferationMAPK kinaseCytoplasmic domainAdhesion kinase