2024
miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression
Fernández-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, Goedeke L, Cadena-Sandoval M, Xirouchaki C, Brown W, Yang X, Pastor-Rojo O, Haeusler R, Bennett A, Tiganis T, Suárez Y, Fernández-Hernando C. miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression. JCI Insight 2024 PMID: 39190492, DOI: 10.1172/jci.insight.168476.Peer-Reviewed Original ResearchMiR-33Regulation of biological processesMitochondrial fatty acid oxidationRegulation of lipid metabolismNon-alcoholic fatty liver diseaseDevelopment of effective therapeuticsFatty acid oxidationLipid synthesisProgression of non-alcoholic fatty liver diseaseMitochondrial functionTarget genesBiological processesComplex diseasesNon-alcoholic steatohepatitisLipid accumulationDeletionDevelopment of non-alcoholic fatty liver diseasePathway activationLipid metabolismProgress to non-alcoholic steatohepatitisAcid oxidationHCC progressionEffective therapeuticsTherapeutic targetHepatocellular carcinoma
2017
Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver
Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan H, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver. Hepatology Communications 2017, 1: 23-35. PMID: 28966992, PMCID: PMC5613674, DOI: 10.1002/hep4.1012.Peer-Reviewed Original ResearchLipid droplet formationFatty liverLiver diseaseHuman fatty liver diseaseFatty liver diseaseNon-alcoholic steatohepatitisDegree of steatosisCalcium signalingHuman liver biopsiesReceptor type 1ER calcium releaseType 1 isoformMitochondrial calcium signalingLiver biopsyHepatic triglyceridesCalcium handlingHepatic expressionKnockout miceTrisphosphate receptor type 1Malignant formUS populationCalcium releaseType 1LiverCommon type