Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses
Chi H, Bennett A, Flavell R. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses. Journal Of Organ Dysfunction 2007, 3: 72-81. DOI: 10.1080/17471060601137415.Peer-Reviewed Original ResearchProtein kinase phosphatase-1Kinase phosphatase-1Innate immune responseMKP-1Toll-like receptorsPhosphatase 1Dual-specificity phosphataseImmune responseC-Jun N-terminal kinaseMKP-1 deficiencyN-terminal kinaseIntracellular negative regulatorTranscriptional inductionExcessive innate immune responseNegative regulatorBiochemical activityCritical regulatorMicrobial pathogensPhysiological functionsPro-inflammatory cytokinesP38 MAPKInnate immunityAutoimmune arthritisDendritic cellsInflammatory mediators