2017
The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions
Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP. The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions. Journal Of Allergy And Clinical Immunology 2017, 142: 1159-1172.e5. PMID: 29157947, PMCID: PMC5957775, DOI: 10.1016/j.jaci.2017.08.046.Peer-Reviewed Original ResearchConceptsIgE-mediated anaphylactic reactionsAnaphylactic reactionsFluid extravasationIL-4RαBarrier dysfunctionIL-4Food-induced anaphylactic reactionsIgE-induced anaphylaxisFood-induced anaphylaxisIgE-mediated anaphylaxisIL-4 receptor α chainIgE-mediated reactionsTreatment of miceSevere anaphylactic reactionsSeverity of anaphylaxisABL kinase inhibitor imatinibKinase inhibitor imatinibReceptor α chainVe cell linesVenous vasodilatationOral antigenHypovolemic shockInhibitor imatinibAnaphylaxisVe cells
2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregions
2014
Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex
Cooper MA, Koleske AJ. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. The Journal Of Comparative Neurology 2014, 522: 3351-3362. PMID: 24752666, PMCID: PMC4107058, DOI: 10.1002/cne.23615.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell FractionationCells, CulturedDendritic SpinesDisks Large Homolog 4 ProteinGene Expression RegulationGreen Fluorescent ProteinsGuanylate KinasesMembrane ProteinsMiceMice, TransgenicMitogen-Activated Protein Kinase 3NestinNeuronsPrefrontal CortexReceptor, ErbB-4SynapsesTransfectionConceptsDendritic spine densitySpine densityExcitatory pyramidal cellsExcitatory neuronsPrefrontal cortexPyramidal cellsDendritic spinesErbB4 functionAblation of ErbB4Dendritic spine lossCortical neuronal culturesMouse prefrontal cortexDendritic spine developmentMonths of ageSynaptic plasma membrane preparationsSpine lossWeanling miceDorsomedial prefrontal cortexPsychiatric disordersKnockout miceMature spinesErbB4 signalingSynaptic plasticityNeuronal culturesDisease pathology
2013
Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior
Kerrisk ME, Greer CA, Koleske AJ. Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior. Journal Of Neuroscience 2013, 33: 6742-6752. PMID: 23595732, PMCID: PMC3711182, DOI: 10.1523/jneurosci.0528-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornBasic Helix-Loop-Helix Transcription FactorsCell MembraneDendritesDendritic SpinesDisks Large Homolog 4 ProteinFemaleGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsGuanylate KinasesHippocampusImmunoprecipitationIntegrin alpha3LysineMaleMembrane ProteinsMemory DisordersMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalNerve Tissue ProteinsNeuronsPhosphopyruvate HydrataseRecognition, PsychologyRhoA GTP-Binding ProteinSynapsesConceptsDendritic spinesIntegrin α3Adult rodent forebrainHippocampal-dependent behaviorsPostnatal day 21Excitatory forebrain neuronsMouse behaviorProper hippocampal functionLong-term potentiationArbor stabilityArg nonreceptor tyrosine kinaseRodent forebrainForebrain neuronsSynapse densitySynapse stabilityDendrite arborsDay 21Arbor sizeHippocampal dendritesHippocampal functionMutant miceSynapse maintenanceBrain functionNeurodegenerative diseasesKey mediatorDelayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice
Couch BA, Kerrisk ME, Kaufman AC, Nygaard HB, Strittmatter SM, Koleske AJ. Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice. The Journal Of Comparative Neurology 2013, 521: 1395-1408. PMID: 23047754, PMCID: PMC3562562, DOI: 10.1002/cne.23239.Peer-Reviewed Original ResearchConceptsAβPP/PS1 micePS1 micePlaque burdenPlaque depositionBehavioral deficitsRadial arm water maze performanceBehavioral impairmentsAlzheimer's diseaseAβPP processingPresenilin 1Amyloid-β precursor proteinLower plaque burdenProgressive neurodegenerative dementiaAmyloid plaque depositionAmyloid plaque accumulationAmyloid plaque burdenAD-like featuresNovel object recognitionWater maze performanceMonths of ageDendrite lossAD progressionNeurodegenerative dementiaPlaque accumulationMixed genetic background
2012
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, DiLeone RJ, Koleske AJ, Taylor JR. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20714-20719. PMID: 23185000, PMCID: PMC3528547, DOI: 10.1073/pnas.1208342109.Peer-Reviewed Original ResearchMeSH KeywordsAffectAmitriptylineAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBrain-Derived Neurotrophic FactorConditioning, PsychologicalCorticosteroneDendritic SpinesGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMifepristoneMotivationPrefrontal CortexRatsRats, Sprague-DawleyReceptors, GlucocorticoidStress, PhysiologicalConceptsGlucocorticoid receptorStress-related mood disordersStressor exposureAdrenal axis feedbackRole of BDNFGlucocorticoid receptor bindingChronic stressor exposureProgressive ratio taskGR blockadeBDNF expressionBDNF knockdownNeurotrophin systemSpine remodelingMood disordersChronic exposureBDNFGR bindingReceptor bindingResponse-outcome learningFood reinforcementAxis feedbackRU38486CorticosteroneStimulus-response associationsMotivational deficitsArg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity
Gourley SL, Olevska A, Warren MS, Taylor JR, Koleske AJ. Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity. Journal Of Neuroscience 2012, 32: 2314-2323. PMID: 22396406, PMCID: PMC3386297, DOI: 10.1523/jneurosci.2730-11.2012.Peer-Reviewed Original ResearchConceptsSpine densityAdolescent wild-type mouseHippocampal CA1 pyramidal neuronsDendritic spine densityCA1 pyramidal neuronsPostnatal day 60Wild-type miceDendritic spine developmentCocaine-Induced PlasticityAddictive-like behaviorsPyramidal neuronsCocaine sensitizationDendritic spinesPsychomotor sensitizationProtective consequencesSpine headsNeuropsychiatric disordersOrbitofrontal cortexDay 60Local applicationArg inhibitionPsychomotor sensitivityIntracellular mechanismsPsychostimulant sensitivitySpine development
2010
Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration
Couch BA, DeMarco GJ, Gourley SL, Koleske AJ. Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration. Journal Of Alzheimer's Disease 2010, 20: 1003-1008. PMID: 20413901, PMCID: PMC3077946, DOI: 10.3233/jad-2010-091114.Peer-Reviewed Original ResearchConceptsDendrite arborsPS1 miceAβPP/PS1 miceAmyloid-beta overproductionPS1 transgenic miceCA1 pyramidal neuronsROCK inhibitor fasudilROCK signalingPyramidal neuronsDendritic regressionFasudil administrationPharmacological reductionInhibitor fasudilTransgenic miceAlzheimer's diseaseMiceDendrite branchingRho-kinaseArborsDiseaseNeuronsSignalingAtrophyFasudilAbeta
2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase