2020
ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice
Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, Qiu W. ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology 2020, 159: 289-305.e16. PMID: 32171747, PMCID: PMC7387191, DOI: 10.1053/j.gastro.2020.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell Line, TumorDatasets as TopicDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansKaplan-Meier EstimateLiverLiver NeoplasmsMaleMicePhosphorylationPrognosisProto-Oncogene MasProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-mycPyrimidinesReceptor, Notch1Xenograft Model Antitumor AssaysConceptsShorter survival timeLiver tumorsExpression of Notch1Hepatocellular carcinomaHuman HCC cellsHCC cellsXenograft tumorsSurvival timeExpression of MYCLiver tissueTreatment of HCCAlbumin-Cre miceNon-tumor liver tissuesABL proto-oncogene 1Nontumor liver tissuesHuman HCC specimensHuh7 HCC cellsHepatocyte-specific disruptionHCC tissue microarrayProto-oncogene 1HCC cell linesShort hairpin RNACancer Genome AtlasKnockdown of Notch1Tumor levels
2012
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, DiLeone RJ, Koleske AJ, Taylor JR. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20714-20719. PMID: 23185000, PMCID: PMC3528547, DOI: 10.1073/pnas.1208342109.Peer-Reviewed Original ResearchMeSH KeywordsAffectAmitriptylineAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBrain-Derived Neurotrophic FactorConditioning, PsychologicalCorticosteroneDendritic SpinesGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMifepristoneMotivationPrefrontal CortexRatsRats, Sprague-DawleyReceptors, GlucocorticoidStress, PhysiologicalConceptsGlucocorticoid receptorStress-related mood disordersStressor exposureAdrenal axis feedbackRole of BDNFGlucocorticoid receptor bindingChronic stressor exposureProgressive ratio taskGR blockadeBDNF expressionBDNF knockdownNeurotrophin systemSpine remodelingMood disordersChronic exposureBDNFGR bindingReceptor bindingResponse-outcome learningFood reinforcementAxis feedbackRU38486CorticosteroneStimulus-response associationsMotivational deficitsArg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo
Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ. Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene 2012, 32: 2622-2630. PMID: 22777352, PMCID: PMC3473103, DOI: 10.1038/onc.2012.284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationErbB ReceptorsFemaleGene Knockdown TechniquesHumansLung NeoplasmsMAP Kinase Signaling SystemMiceMice, SCIDNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationProto-Oncogene Proteins c-ablSrc-Family KinasesTransplantation, HeterologousConceptsTumor cell invasionBreast cancer cellsTyrosine kinaseCancer cellsCell invasionNon-receptor tyrosine kinaseRas-MAPK signalingRas-MAPK pathwayGene expression patternsSrc tyrosine kinaseInvasion-associated genesUncontrolled cell divisionProliferation-associated genesMetastatic cancer cellsCell divisionExpression patternsEGF receptorTumor cell proliferationPromotes InvasionMouse xenograft modelCell proliferationMultistep processGenetic aberrationsKinaseGenes
2011
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
Chung C, Mader CC, Schmitz J, Atladottir J, Fitchev P, Cornwell M, Koleske AJ, Crawford SE, Gorelick F. The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer. Laboratory Investigation 2011, 91: 732-743. PMID: 21339745, PMCID: PMC3084324, DOI: 10.1038/labinvest.2011.8.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaMMP-9 activityHuman pancreatic cancerPancreatic cancerPanIN lesionsHigh-grade PanIN lesionsHuman pancreatic ductal adenocarcinomaPancreatic intraepithelial neoplasmsCancer cellsLow-grade PanIN lesionsMatrix metalloproteinase activationMMP-2 activityPancreatic cancer cellsHuman cancer tissuesShort hairpin RNAPancreatic histologyIntraepithelial neoplasmDuctal adenocarcinomaNormal ductsMMP releaseCancer tissuesMMP-2Metalloproteinase activationInvasive propertiesSpecific MMPs