2015
Structure of the ABL2/ARG kinase in complex with dasatinib
Ha BH, Simpson MA, Koleske AJ, Boggon TJ. Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallographica Section F: Structural Biology Communications 2015, 71: 443-448. PMID: 25849507, PMCID: PMC4388181, DOI: 10.1107/s2053230x15004793.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDasatinibHumansMiceProtein Kinase InhibitorsProtein Structure, SecondaryProtein Structure, TertiaryProtein-Tyrosine KinasesConceptsT-cell acute lymphoblastic leukemiaActivation loop tyrosinesABL kinase activationGlycine-rich P-loopCell morphogenesisCo-crystal structureBreakpoint cluster regionCellular functionsArg genesCatalytic domainAbl familyArg kinaseP-loopKinase activationBiological roleOpen conformationTyrosine kinaseAbl kinaseKinaseGenesKinase inhibitorsABL1 geneArgCluster regionTyrosine kinase inhibitors
2010
Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration
Couch BA, DeMarco GJ, Gourley SL, Koleske AJ. Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration. Journal Of Alzheimer's Disease 2010, 20: 1003-1008. PMID: 20413901, PMCID: PMC3077946, DOI: 10.3233/jad-2010-091114.Peer-Reviewed Original ResearchConceptsDendrite arborsPS1 miceAβPP/PS1 miceAmyloid-beta overproductionPS1 transgenic miceCA1 pyramidal neuronsROCK inhibitor fasudilROCK signalingPyramidal neuronsDendritic regressionFasudil administrationPharmacological reductionInhibitor fasudilTransgenic miceAlzheimer's diseaseMiceDendrite branchingRho-kinaseArborsDiseaseNeuronsSignalingAtrophyFasudilAbeta
2007
Dissecting kinase signaling pathways
Boyle SN, Koleske AJ. Dissecting kinase signaling pathways. Drug Discovery Today 2007, 12: 717-724. PMID: 17826684, DOI: 10.1016/j.drudis.2007.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBenzamidesDrug Delivery SystemsHumansImatinib MesylateLapatinibNeoplasmsPhosphoproteinsPhosphorylationPiperazinesProtein Kinase InhibitorsProtein KinasesProteomicsPyrimidinesQuinazolinesSignal TransductionTrastuzumabConceptsSame protein substrateProtein Kinase SignalingKinase substratePutative substratesProtein substratesKinase signalingProtein kinaseMultiple kinasesPhysiological substratesKinaseHuman diseasesDrug targetsPhysiological relevanceSubstrate interactionsKinase inhibitorsPathwaySignalingSubstrateNeurological disordersInteractionHallmarkInhibitorsTarget