Reduction of caveolin and caveolae in oncogenically transformed cells.
Koleske AJ, Baltimore D, Lisanti MP. Reduction of caveolin and caveolae in oncogenically transformed cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 1381-1385. PMID: 7877987, PMCID: PMC42523, DOI: 10.1073/pnas.92.5.1381.Peer-Reviewed Original ResearchConceptsPlasma membraneTransduction of signalsNIH 3T3 cellsSize of coloniesOncogenic transformationCaveolaeProtein coatCaveolinDemonstrated roleContact inhibitionCellular levelSoft agarElectron microscopy revealsCell linesCritical roleMicroscopy revealsCellsMembranePotocytosisTransductionFunctional alterationsOncogeneInvaginationColoniesRoleCaveolae, transmembrane signalling and cellular transformation
Lisanti M, Tang Z, Scherer P, Kübler E, Koleske A, Sargiacomo M. Caveolae, transmembrane signalling and cellular transformation. Molecular Membrane Biology 1995, 12: 121-124. PMID: 7767370, DOI: 10.3109/09687689509038506.Peer-Reviewed Original ResearchConceptsCaveolin-rich membrane domainsV-Src substrateCaveolar marker proteinCaveolar functionSmall moleculesMembrane domainsCellular transformationPlasma membraneCaveolaeMarker proteinsCultured cellsCapillary endothelial cellsProteinEndothelial cellsCellsMembraneCaveolinTransmembraneCytoplasmGPITranslocationElectron micrographsMoleculesWide varietyTranscytosis