2017
CNS Neurons Deposit Laminin α5 to Stabilize Synapses
Omar MH, Campbell M, Xiao X, Zhong Q, Brunken WJ, Miner JH, Greer CA, Koleske AJ. CNS Neurons Deposit Laminin α5 to Stabilize Synapses. Cell Reports 2017, 21: 1281-1292. PMID: 29091766, PMCID: PMC5776391, DOI: 10.1016/j.celrep.2017.10.028.Peer-Reviewed Original ResearchConceptsDendritic spine head sizeLaminin α5Larger postsynaptic densitiesDendritic spine densitySpine head sizeAge-dependent lossDendritic spine sizeEnhanced neurotransmissionSpine densityHippocampal neuronsDendritic spinesConditional deletionLaminin β2Postsynaptic densitySynapsesSpine sizeEarly adulthoodBehavioral defectsNeuronsBrainHead sizeMolecular mechanismsΑ5LamininNeurotransmission
2013
Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience
Gourley SL, Swanson AM, Koleske AJ. Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience. Journal Of Neuroscience 2013, 33: 3107-3112. PMID: 23407965, PMCID: PMC3711631, DOI: 10.1523/jneurosci.2138-12.2013.Peer-Reviewed Original ResearchConceptsStressor exposureDendritic spinesDendritic spine densityRecovery periodCA1 pyramidal neuronsHippocampal CA1 neuronsCertain neuron populationsStress hormone exposureStress-related modificationsDistinct brain regionsBehavioral vulnerabilityDendritic retractionPyramidal neuronsCA1 neuronsNeural remodelingSpine densityStress-related diseasesHippocampal CA1Orbital cortexBasal amygdalaDendritic arborsHormone exposureNeuron populationsBrain regionsBrain circuits
2012
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, DiLeone RJ, Koleske AJ, Taylor JR. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20714-20719. PMID: 23185000, PMCID: PMC3528547, DOI: 10.1073/pnas.1208342109.Peer-Reviewed Original ResearchMeSH KeywordsAffectAmitriptylineAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBrain-Derived Neurotrophic FactorConditioning, PsychologicalCorticosteroneDendritic SpinesGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMifepristoneMotivationPrefrontal CortexRatsRats, Sprague-DawleyReceptors, GlucocorticoidStress, PhysiologicalConceptsGlucocorticoid receptorStress-related mood disordersStressor exposureAdrenal axis feedbackRole of BDNFGlucocorticoid receptor bindingChronic stressor exposureProgressive ratio taskGR blockadeBDNF expressionBDNF knockdownNeurotrophin systemSpine remodelingMood disordersChronic exposureBDNFGR bindingReceptor bindingResponse-outcome learningFood reinforcementAxis feedbackRU38486CorticosteroneStimulus-response associationsMotivational deficits
2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase