Reduction of caveolin and caveolae in oncogenically transformed cells.
Koleske AJ, Baltimore D, Lisanti MP. Reduction of caveolin and caveolae in oncogenically transformed cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 1381-1385. PMID: 7877987, PMCID: PMC42523, DOI: 10.1073/pnas.92.5.1381.Peer-Reviewed Original ResearchConceptsPlasma membraneTransduction of signalsNIH 3T3 cellsSize of coloniesOncogenic transformationCaveolaeProtein coatCaveolinDemonstrated roleContact inhibitionCellular levelSoft agarElectron microscopy revealsCell linesCritical roleMicroscopy revealsCellsMembranePotocytosisTransductionFunctional alterationsOncogeneInvaginationColoniesRoleCaveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity
Lisanti M, Scherer P, Tang Z, Kübler E, Koleske A, Sargiacomo M. Caveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity. Seminars In Cell And Developmental Biology 1995, 6: 47-58. DOI: 10.1016/s1044-5781(06)80084-8.Peer-Reviewed Original ResearchHeterotrimeric G proteinsSrc-like kinasesTranscytosis of macromoleculesCertain transmembraneCell polarityRap GTPasesAnion transport proteinMembrane porinsBiochemical isolationPlasma membraneDiverse functionsTransport proteinsG proteinsCell transformationHuman diseasesMolecular componentsFunctional roleMembranous structuresCaveolaeEpithelial cellsMolecular pathogenesisScavenger receptorsSmall moleculesCapillary endothelial cellsGPICaveolae, transmembrane signalling and cellular transformation
Lisanti M, Tang Z, Scherer P, Kübler E, Koleske A, Sargiacomo M. Caveolae, transmembrane signalling and cellular transformation. Molecular Membrane Biology 1995, 12: 121-124. PMID: 7767370, DOI: 10.3109/09687689509038506.Peer-Reviewed Original ResearchConceptsCaveolin-rich membrane domainsV-Src substrateCaveolar marker proteinCaveolar functionSmall moleculesMembrane domainsCellular transformationPlasma membraneCaveolaeMarker proteinsCultured cellsCapillary endothelial cellsProteinEndothelial cellsCellsMembraneCaveolinTransmembraneCytoplasmGPITranslocationElectron micrographsMoleculesWide varietyTranscytosis