2014
Chapter 5 ECM receptors in neuronal structure, synaptic plasticity, and behavior
Kerrisk ME, Cingolani LA, Koleske AJ. Chapter 5 ECM receptors in neuronal structure, synaptic plasticity, and behavior. Progress In Brain Research 2014, 214: 101-131. PMID: 25410355, PMCID: PMC4640673, DOI: 10.1016/b978-0-444-63486-3.00005-0.Peer-Reviewed Original ResearchConceptsSynaptic plasticityNeuronal structuresCentral nervous system developmentForm synapsesNervous system developmentDendritic projectionsSynaptic activityPostsynaptic partnersPostsynaptic cellECM receptorsReceptor activationGuidance moleculesSynapse structureReceptorsStable synapsesExtracellular matrix receptorsNeuronsSynapsesCell adhesion receptorsMatrix receptorsAdhesion receptorsReceptor transitionPreECM compositionECM ligands
2012
Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior
Warren MS, Bradley WD, Gourley SL, Lin YC, Simpson MA, Reichardt LF, Greer CA, Taylor JR, Koleske AJ. Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior. Journal Of Neuroscience 2012, 32: 2824-2834. PMID: 22357865, PMCID: PMC3313657, DOI: 10.1523/jneurosci.3942-11.2012.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornAvoidance LearningBasic Helix-Loop-Helix Transcription FactorsCells, CulturedCocaineDendritesEnzyme-Linked Immunosorbent AssayExploratory BehaviorGreen Fluorescent ProteinsGTPase-Activating ProteinsHippocampusImmunoprecipitationIntegrin beta1MaleMiceMice, KnockoutMutationNerve Tissue ProteinsNeuronsOrgan Culture TechniquesPost-Synaptic DensityProtein BindingRecognition, PsychologyRepressor ProteinsSignal TransductionSrc Homology DomainsSynapsesConceptsIntegrin β1Vertebrate nervous systemExtracellular matrix receptorsGenetic experimentsIntracellular tailGenetic manipulationRhoA GTPaseArg kinaseMatrix receptorsProper hippocampal functionProper developmentSynapse maintenanceDose-sensitive mannerImpaired hippocampus-dependent learningHippocampal dendritic arborsHippocampal synapse lossDendritic arbor sizeHippocampus-dependent learningΒ1ArgSelective lossGTPaseP190RhoGAPPsychomotor sensitivityKinase