2021
Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts
Bircher JE, Koleske AJ. Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts. Journal Of Cell Science 2021, 134: jcs248393. PMID: 33568469, PMCID: PMC7888718, DOI: 10.1242/jcs.248393.Peer-Reviewed Original ResearchConceptsFamily proteinsCellular contextProtein-protein interaction domainsHuman diseasesProtein trafficking pathwaysLarge multidomain proteinCell surface receptorsTrio proteinsUNC-73Cell morphogenesisProtein traffickingTrafficking pathwaysMultidomain proteinsInteraction domainInteraction partnersKey regulatorBiological contextTissue organizationCell migrationSurface receptorsProteinTrio familiesRecent discoveryMorphogenesisRegulator
2007
Dissecting kinase signaling pathways
Boyle SN, Koleske AJ. Dissecting kinase signaling pathways. Drug Discovery Today 2007, 12: 717-724. PMID: 17826684, DOI: 10.1016/j.drudis.2007.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBenzamidesDrug Delivery SystemsHumansImatinib MesylateLapatinibNeoplasmsPhosphoproteinsPhosphorylationPiperazinesProtein Kinase InhibitorsProtein KinasesProteomicsPyrimidinesQuinazolinesSignal TransductionTrastuzumabConceptsSame protein substrateProtein Kinase SignalingKinase substratePutative substratesProtein substratesKinase signalingProtein kinaseMultiple kinasesPhysiological substratesKinaseHuman diseasesDrug targetsPhysiological relevanceSubstrate interactionsKinase inhibitorsPathwaySignalingSubstrateNeurological disordersInteractionHallmarkInhibitorsTarget
1995
Caveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity
Lisanti M, Scherer P, Tang Z, Kübler E, Koleske A, Sargiacomo M. Caveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity. Seminars In Cell And Developmental Biology 1995, 6: 47-58. DOI: 10.1016/s1044-5781(06)80084-8.Peer-Reviewed Original ResearchHeterotrimeric G proteinsSrc-like kinasesTranscytosis of macromoleculesCertain transmembraneCell polarityRap GTPasesAnion transport proteinMembrane porinsBiochemical isolationPlasma membraneDiverse functionsTransport proteinsG proteinsCell transformationHuman diseasesMolecular componentsFunctional roleMembranous structuresCaveolaeEpithelial cellsMolecular pathogenesisScavenger receptorsSmall moleculesCapillary endothelial cellsGPI