2019
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Journal Of Clinical Investigation 2019, 129: 4863-4874. PMID: 31408443, PMCID: PMC6819111, DOI: 10.1172/jci127692.Peer-Reviewed Original ResearchConceptsPP2A regulatory subunit B55αTranscription factor YAPActive PDEComplex assemblyAdapter rolePDE4D5B55αIntegrin α5EC phenotypeCell functionInflammatory signalingAthero-prone regionsActivationComplexesPP2AInflammatory activationWidespread consequencesDephosphorylationProteomicsVascular remodelingPlaque sizeAtherosclerotic plaque sizeSignalingYAPRegulates
2017
The Abl‐1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education
Ganesan S, Luu TT, Chambers BJ, Meinke S, Brodin P, Vivier E, Wetzel DM, Koleske AJ, Kadri N, Höglund P. The Abl‐1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education. Scandinavian Journal Of Immunology 2017, 86: 135-142. PMID: 28605050, PMCID: PMC5568956, DOI: 10.1111/sji.12574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCells, CulturedCytotoxicity, ImmunologicImmunity, InnateInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNatural Cytotoxicity Triggering Receptor 1NK Cell Lectin-Like Receptor Subfamily CProto-Oncogene Proteins c-ablSignal TransductionConceptsNK cell educationNK cellsCell educationNatural killer cell responsivenessYAC-1 tumor cellsNK cell inhibitionNK cell functionHuman NK cellsMurine NK cellsMHC class IC-AblC-Abl expressionInhibitory Ly49Normal inhibitoryNKG2A receptorsInhibitory receptorsCell responsivenessReceptor stimulationReceptor repertoireInhibitory signalingTumor cellsITAM receptorsClass ICell inhibitionCell function
2008
T cell survival and function requires the c-Abl tyrosine kinase
Silberman I, Sionov RV, Zuckerman V, Haupt S, Goldberg Z, Strasser A, Ben-Sasson ZS, Baniyash M, Koleske AJ, Haupt Y. T cell survival and function requires the c-Abl tyrosine kinase. Cell Cycle 2008, 7: 3847-3857. PMID: 19098427, PMCID: PMC3407662, DOI: 10.4161/cc.7.24.7267.Peer-Reviewed Original ResearchConceptsT cellsThymic atrophyT cell numbersAnti-tumor antibodiesAdult T-cellT cell functionT cell survivalDeficient T cellsTumor cell killingLck-Cre transgeneSyngeneic tumorsCell-autonomous roleEarly deathImmune systemIncreased susceptibilityMiceImpaired abilityCell functionAtrophyCell killingCell numberSurvivalOxidative stress stimuliCell survivalRole of Abl