Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity
Düsterhöft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Röseler J, Reiss K, Grötzinger J, Lorenzen I. Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity. Biochemistry 2015, 54: 5791-5801. PMID: 26348730, DOI: 10.1021/acs.biochem.5b00497.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAM17 ProteinAmino Acid SequenceAnimalsCell LineCell MembraneHep G2 CellsHumansHydrophobic and Hydrophilic InteractionsLipid BilayersMiceMolecular Sequence DataMutationProtein Interaction Domains and MotifsSubstrate SpecificityConceptsMembrane-proximal domainJuxtamembrane segmentSubstrate recognitionMembrane-anchored proteinsAmino acid residuesActivity of ADAM17Extracellular regionBiological processesMajor sheddasesAcid residuesCancer progressionLipid bilayersMetalloprotease 17Key mediatorInterleukin-6 receptorDisintegrinADAM17SheddasesDomainProteinInteractsResiduesDifferentiationActivityWide variety