Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice
Veit M, Ahrens B, Seidel J, Sommer A, Bhakdi S, Reiss K. Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice. Life Science Alliance 2019, 2: e201900430. PMID: 31455669, PMCID: PMC6712283, DOI: 10.26508/lsa.201900430.Peer-Reviewed Original ResearchConceptsEmbryonic lethalityVital cellular functionsAnionic phospholipid headgroupsTransmembrane substratesCellular functionsProtease functionBinding motifAmino acidsCell surfaceMutant proteasePrimary hepatocytesMotifMutagenesisPhosphatidylserinePhospholipid headgroupsProminent memberCentral roleEssential triggerLethalitySurface exposureOncogenesisProteaseADAM17DisintegrinMice