Smoothening out the patches
Sommer A, Lemmon MA. Smoothening out the patches. Science 2018, 362: 26-27. PMID: 30287647, PMCID: PMC6421564, DOI: 10.1126/science.aav1025.Peer-Reviewed Original ResearchConceptsProtein PatchedTransmembrane protein PatchedCryo-electron microscopyRecent crystal structureUnique molecular mechanismImportant tumor suppressorKey HedgehogImportant new insightsMolecular mechanismsTumor suppressorMolecular eventsHedgehogCell membranePathwayCholesterol transportNew insightsNew roleHomologous ligandsMetazoansPatchedSmoothenedSuppressorRecent reportsProteinCrystal structure