Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding
Sommer A, Düppe M, Baumecker L, Kordowski F, Büch J, Chico J, Fritsch J, Schütze S, Adam D, Sperrhacke M, Bhakdi S, Reiss K. Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding. Oncotarget 2017, 5: 72584-72596. PMID: 29069811, PMCID: PMC5641154, DOI: 10.18632/oncotarget.19983.Peer-Reviewed Original ResearchHuman umbilical vein endothelial cellsEndothelial cell deathCell deathTNF-α receptor 1COS7 cellsVital cellular functionsPhospholipid scramblasesSheddase functionCellular functionsEffect of SMaseADAM activityExtracellular sphingomyelinaseSignaling cascadesEndothelial cellsUmbilical vein endothelial cellsReceptor 1Phospholipid asymmetryPS externalizationSheddase activityCell survivalImportant regulatorVein endothelial cellsCell typesEndothelial cell functionEndothelial cell proliferation