2024
Inflammation and Ovarian Function in Reproductive‐Aged Women
Long A, Steiner A, Thompson A, Jahnke H, Harris B, Jukic A. Inflammation and Ovarian Function in Reproductive‐Aged Women. American Journal Of Human Biology 2024, e24196. PMID: 39623697, DOI: 10.1002/ajhb.24196.Peer-Reviewed Original ResearchFollicle-stimulating hormoneC-reactive proteinAnti-Mullerian hormoneOvarian functionInhibin BOvarian reserveFollicular phase follicle-stimulating hormoneMarkers of immune activationBiomarker of ovarian functionTime to ConceiveInhibin B levelsDiminished ovarian reserveAnti-Mullerian hormone levelsCross-sectional analysis of dataPolycystic ovarian syndromeCohort study sampleSecondary cross-sectional analysisNatural-logInhibin B.Menstrual cycleImmune activationLogistic regression modelsFollicular phaseHormone levelsHigher inflammationEarly‐life menstrual characteristics and gestational diabetes in a large US cohort
Wang Z, Baird D, Williams M, Jukic A, Wilcox A, Curry C, Fischer‐Colbrie T, Onnela J, Hauser R, Coull B, Mahalingaiah S. Early‐life menstrual characteristics and gestational diabetes in a large US cohort. Paediatric And Perinatal Epidemiology 2024, 38: 654-665. PMID: 39607069, PMCID: PMC11603761, DOI: 10.1111/ppe.13129.Peer-Reviewed Original ResearchConceptsMenstrual cycle characteristicsAssociated with GDMGestational diabetesMenstrual characteristicsEarly menarcheHigher risk of GDMRisk of GDMEvaluate associationsPoisson generalised estimating equationsAssociated with higher riskModified Poisson regressionGDM historyRecurrent GDMLive birthsEarly-life factorsGDMPregnancyUS cohortRecurrenceCycle regularityGeneralised estimating equationsMenarcheLogistic regressionDiabetesPoisson regressionThe Menstrual Cycle as a Vital Sign: a comprehensive review
Vollmar A, Mahalingaiah S, Jukic A. The Menstrual Cycle as a Vital Sign: a comprehensive review. F&S Reviews 2024, 100081. DOI: 10.1016/j.xfnr.2024.100081.Peer-Reviewed Original ResearchClinical practice guidelinesHealth outcomesPractice guidelinesVital signsMedical professional organizationsInclusion of systematic reviewsMenstrual cyclePatient handoutsHealth indicatorsGeneral healthHealth conditionsOptimal wellnessMenstrual cycle patternSystematic reviewMeta-analysesProfessional organizationsLiterature searchHealthScientific evidenceClinical courseReview exposureGuidelinesOutcomesIn adulthoodReviewSigns of Potential Androgen Excess Across the Lifespan in a US-based Digital Cohort Study
Wolf A, Wang Z, Onnela J, Baird D, Jukic A, Curry C, Fischer-Colbrie T, Williams M, Hauser R, Coull B, Mahalingaiah S. Signs of Potential Androgen Excess Across the Lifespan in a US-based Digital Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae674. PMID: 39388314, DOI: 10.1210/clinem/dgae674.Peer-Reviewed Original ResearchVitamin D Levels in the United States: Temporal Trends (2011–2018) and Contemporary Associations with Sociodemographic Characteristics (2017–2018)
Subramanian A, Burrowes H, Rumph J, Wilkerson J, Jackson C, Jukic A. Vitamin D Levels in the United States: Temporal Trends (2011–2018) and Contemporary Associations with Sociodemographic Characteristics (2017–2018). Nutrients 2024, 16: 3414. PMID: 39408379, PMCID: PMC11478591, DOI: 10.3390/nu16193414.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyNon-Hispanic black femalesVitamin D levelsNational Health and Nutrition Examination Surveys survey cyclesHealth and Nutrition Examination SurveyNon-Hispanic blacksAssociated with larger decrementsNutrition Examination SurveyMedian 25(OH)DD levelsPredictors of 25(OH)D levelsMultivariate linear regressionExamination SurveyPrevalence of 25(OH)DSurvey cyclesWeighted medianLevels of 25(OH)DSociodemographic characteristicsVitamin D supplementationFemales of reproductive ageHigher BMILow-incomeIncreased BMIMexican AmericansVitamin D data7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro
Yi M, Wang T, Jukic A, DeMayo F. 7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro. Journal Of The Endocrine Society 2024, 8: bvae163.1783. PMCID: PMC11454223, DOI: 10.1210/jendso/bvae163.1783.Peer-Reviewed Original ResearchVitamin D receptorVitamin D signalingVitamin DIngenuity Pathway AnalysisTreatment of 1,25(OH)<sub>2</sub>D<sub>3</sub> atDecidualization markersUterine stromal cell differentiationD signalingKnockdown of VDRUterine decidual reactionHuman endometrial stroma cellsExpression of decidualization markersVitamin D-deficient dietAbility of estrogenStromal cell differentiationD-deficient dietEndometrial stromal cellsIn vitro decidualizationEndometrial stroma cellsUpstream regulatorVitamin D receptor siRNATranscription factor vitamin D receptorResponse to exogenous hormonesB-estradiolDecidual reactionAMBIENT AIR POLLUTION AND FECUNDABILITY IN A PRECONCEPTION TIME-TO-PREGNANCY COHORT
Klawans M, Buller I, Konrad K, Jahnke H, Keil A, McConnaughey D, Steiner A, Jukic A. AMBIENT AIR POLLUTION AND FECUNDABILITY IN A PRECONCEPTION TIME-TO-PREGNANCY COHORT. Fertility And Sterility 2024, 122: e253. DOI: 10.1016/j.fertnstert.2024.07.793.Peer-Reviewed Original ResearchPREDICTION OF POLYCYSTIC OVARY SYNDROME (PCOS) USING SELF-REPORTED CHARACTERISTICS FROM A DIGITAL COHORT IN THE UNITES STATES
Wang Z, Wolf A, Asokan G, Onnela J, Baird D, Jukic A, Wilcox A, Williams M, Hauser R, Coull B, Mahalingaiah S. PREDICTION OF POLYCYSTIC OVARY SYNDROME (PCOS) USING SELF-REPORTED CHARACTERISTICS FROM A DIGITAL COHORT IN THE UNITES STATES. Fertility And Sterility 2024, 122: e358. DOI: 10.1016/j.fertnstert.2024.08.113.Peer-Reviewed Original ResearchVITAMIN D AND CYCLE LENGTH IN A PROSPECTIVE COHORT STUDY
Jukic A, Harmon Q, Baird D. VITAMIN D AND CYCLE LENGTH IN A PROSPECTIVE COHORT STUDY. Fertility And Sterility 2024, 122: e86. DOI: 10.1016/j.fertnstert.2024.07.306.Peer-Reviewed Original ResearchTrends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health study
Mishra A, Park J, Shapiro I, Fisher-Colbrie T, Baird D, Suharwardy S, Zhang S, Jukic A, Curry C. Trends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health study. AJOG Global Reports 2024, 4: 100388. PMID: 39296604, PMCID: PMC11408385, DOI: 10.1016/j.xagr.2024.100388.Peer-Reviewed Original ResearchApple Women's Health StudyWomen's Health StudyHealth metricsHealth StudyResting heart ratePre-pregnancyHeart rate variabilityBehavioral changesThird trimesterExercise minutesStep countsCardio fitnessWeeks postpartumPregnancy startHeart rateDescriptive DataPostpartumSleep durationRate variabilityWeeks of pregnancyMeasures of activityDemographic factorsTotal sleep durationObservational studyU.S. residentsPrevalence and Trends in Vitamin D Levels in the United States, 2011-2018
Subramanian A, Burrowes H, Rumph J, Wilkerson J, Jukic A. Prevalence and Trends in Vitamin D Levels in the United States, 2011-2018. Current Developments In Nutrition 2024, 8: 103800. DOI: 10.1016/j.cdnut.2024.103800.Peer-Reviewed Original ResearchVitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Fisher M, Weiler H, Kuiper J, Borghese M, Buckley J, Shutt R, Ashley-Martin J, Subramanian A, Arbuckle T, Potter B, Little J, Morisset A, Jukic A. Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective. Current Epidemiology Reports 2024, 11: 153-163. PMID: 39156920, PMCID: PMC11329583, DOI: 10.1007/s40471-024-00348-0.Peer-Reviewed Original ResearchVitamin DPregnant womenHigher vitamin D statusToxic metalsPrevention of adverse outcomesTrials of vitamin D supplementationVitamin D statusVitamin D supplementationOverall nutritional statusNutritional interventionPotential biological mechanismsPregnant populationEpidemiological studiesBlood metalsNutritional statusD statusD supplementationNorth American studiesProspective studyAdverse outcomesAbsorption of metalsPregnancyIntestinal absorptionMetal exposureEndocrine disruptionIrregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort
Wang Z, Jukic A, Baird D, Wilcox A, Li H, Curry C, Fischer-Colbrie T, Onnela J, Williams M, Hauser R, Coull B, Mahalingaiah S. Irregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort. JAMA Network Open 2024, 7: e249657. PMID: 38700861, PMCID: PMC11069087, DOI: 10.1001/jamanetworkopen.2024.9657.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeCardiometabolic conditionsPrevalence odds ratiosAssociated with type 2 diabetesTransient ischemic attackType 2 diabetesAssociation of polycystic ovary syndromeIrregular menstrual cyclesEstimate prevalence odds ratiosCoronary artery diseaseOvulatory disordersHeart attackHigh cholesterolPolycystic ovary syndrome statusIrregular cyclesLower body mass indexCross-sectional studyAge of consentBody mass indexLogistic regression modelsMenstrual cyclePhysical activityLifestyle factorsArtery diseaseEffect modificationMenarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US
Wang Z, Asokan G, Onnela J, Baird D, Jukic A, Wilcox A, Curry C, Fischer-Colbrie T, Williams M, Hauser R, Coull B, Mahalingaiah S. Menarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US. JAMA Network Open 2024, 7: e2412854. PMID: 38809557, PMCID: PMC11137638, DOI: 10.1001/jamanetworkopen.2024.12854.Peer-Reviewed Original ResearchConceptsBody mass indexAdverse health outcomesEarly menarcheHealth outcomesSocioeconomic statusBirth yearCohort studyAssociated with adverse health outcomesNon-Hispanic blacksEarly-life characteristicsParticipants self-ratedEthnic minority groupsTemporal trendsSociodemographic factorsExploratory mediation analysisMain OutcomesUS cohortLate menarcheMass indexCycle regularitySelf-ratingsMenarcheHealth implicationsMediation analysisParticipantsVitamin D status and supplementation, calcium supplementation, and timing of natural menopause
Jukic A, Sandler D, Weinberg C, O'Brien K. Vitamin D status and supplementation, calcium supplementation, and timing of natural menopause. Maturitas 2024, 182: 107916. PMID: 38266360, PMCID: PMC11000149, DOI: 10.1016/j.maturitas.2024.107916.Peer-Reviewed Original ResearchConceptsCalcium supplement useTiming of natural menopauseVitamin D statusTime of menopauseNatural menopauseFollow-upVitamin DSupplement useD statusMenstrual periodAssociated with timing of menopauseHazard ratioMultivariate Cox proportional hazards modelAssociated with ovarian reserveVitamin D supplement useYears of follow-upVitamin D supplementationLoss to follow-upCox proportional hazards modelsFollow-up time pointsYear follow-upBody mass indexConfidence intervalsSister Study cohortEstimate hazard ratios
2023
Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women
Subramanian A, Harmon Q, Bernardi L, Carnethon M, Marsh E, Baird D, Jukic A. Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women. Fertility And Sterility 2023, 121: 642-650. PMID: 38145700, PMCID: PMC10978232, DOI: 10.1016/j.fertnstert.2023.12.023.Peer-Reviewed Original ResearchHigher AMH levelsLower AMH levelsAMH levelsAfrican American womenHigher oddsMAIN OUTCOMELower oddsAntimüllerian hormone levelsSerum AMH levelsPolycystic ovary syndromeHormonal contraceptive useBody mass indexTime of enrollmentCross-sectional studyExclusion of participantsClinical trial designAntimüllerian hormoneOvarian reserveOvary syndromeProspective cohortMass indexPrior diagnosisD levelsHormone levelsContraceptive useRacial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Welch B, Keil A, Buckley J, Engel S, James-Todd T, Zota A, Alshawabkeh A, Barrett E, Bloom M, Bush N, Cordero J, Dabelea D, Eskenazi B, Lanphear B, Padmanabhan V, Sathyanarayana S, Swan S, Aalborg J, Baird D, Binder A, Bradman A, Braun J, Calafat A, Cantonwine D, Christenbury K, Factor-Litvak P, Harley K, Hauser R, Herbstman J, Hertz-Picciotto I, Holland N, Jukic A, McElrath T, Meeker J, Messerlian C, Michels K, Newman R, Nguyen R, O’Brien K, Rauh V, Redmon B, Rich D, Rosen E, Schmidt R, Sparks A, Starling A, Wang C, Watkins D, Weinberg C, Weinberger B, Wenzel A, Wilcox A, Yolton K, Zhang Y, Ferguson K. Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts. Environmental Health Perspectives 2023, 131: 127015. PMID: 38117586, PMCID: PMC10732302, DOI: 10.1289/ehp12831.Peer-Reviewed Original ResearchConceptsPhthalate metabolite concentrationsPreterm birthPhthalate exposurePhthalate metabolitesEthnic disparitiesU.S. cohortHypothetical interventionUrinary phthalate metabolite concentrationsMetabolite concentrationsWhite participantsUrinary phthalate metabolitesCovariate-adjusted differencesLatina participantsExposure-response modelPooled studiesOdds ratioPacific Islander participantsAsian/Pacific Islander participantsLogistic regressionMetabolite levelsBirthPregnancyPositive associationInterventionCohortSeasonal variations of menstrual cycle length in a large, US-based, digital cohort
Li H, Curry C, Fischer-Colbrie T, Onnela J, Williams M, Hauser R, Coull B, Jukic A, Mahalingaiah S. Seasonal variations of menstrual cycle length in a large, US-based, digital cohort. International Journal Of Hygiene And Environmental Health 2023, 256: 114308. PMID: 38103472, PMCID: PMC10872302, DOI: 10.1016/j.ijheh.2023.114308.Peer-Reviewed Original Research
2017
Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision
Jukic AMZ, Hoofnagle AN, Lutsey PL. Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision. American Journal Of Epidemiology 2017, 187: 879-890. PMID: 29020155, PMCID: PMC5889008, DOI: 10.1093/aje/kwx297.Peer-Reviewed Original ResearchConceptsVitamin D statusVitamin DD statusIndividual's vitamin D statusFat-soluble vitaminsCardiovascular diseaseEpidemiologic studiesHealth outcomesReproductive functionIdeal interventionClinical researchDietary supplementsAvailable supplementsBiomarkersImportant considerationNew research studiesLow levelsSupplementsDate synthesisStatusEpidemiologicCancerInfectionDiseaseDramatic increase
2016
Long-term Recall of Time to Pregnancy
Jukic AM, McConnaughey DR, Weinberg CR, Wilcox AJ, Baird DD. Long-term Recall of Time to Pregnancy. Epidemiology 2016, 27: 705-711. PMID: 27487038, PMCID: PMC5444084, DOI: 10.1097/ede.0000000000000506.Peer-Reviewed Original ResearchConceptsPositive predictive valuePregnancy attemptsPregnancy dataProspective timeNorth Carolina Early Pregnancy StudyPredictive valueEarly Pregnancy StudyLifetime reproductive historiesWeighted kappa statisticHigher gravidityProspective dataRisk factorsChronic diseasesPregnancy StudyPregnancySmall studyReproductive historyLower likelihoodWomenKappa statisticsLong-term recallFuture studiesLower proportionGravidityWidespread use