Featured Publications
Deep Vein Thrombosis: Update on Mechanical Thrombectomy and Intravascular US.
Sailer A, Revzin MV, Pollak J, Ayyagari R, Mojibian HR, Nezami N, Pellerito JS, Marino AG. Deep Vein Thrombosis: Update on Mechanical Thrombectomy and Intravascular US. RadioGraphics 2022, 42: e184-e185. PMID: 36190870, DOI: 10.1148/rg.220031.Peer-Reviewed Original ResearchSequelae of Eating Disorders at Imaging
Solomon N, Sailer A, Dixe de Oliveira Santo I, Pillai A, Heng LXX, Jha P, Katz DS, Zulfiqar M, Sugi M, Revzin MV. Sequelae of Eating Disorders at Imaging. RadioGraphics 2022, 42: 1377-1397. PMID: 35930473, DOI: 10.1148/rg.220018.Peer-Reviewed Educational MaterialsConceptsMedical historyPatient's medical historyHigh mortality rateOverview of managementClinical presentationMedical complicationsRelated complicationsImaging findingsPhysical examinationUncommon sequelaMedical attentionOnline supplemental materialPsychiatric disordersMedical treatmentMortality rateOrgan systemsSequelaeDisordersDiagnosisComplicationsPatientsPathophysiologySocial stigmaLaboratory resultsRadiologistsAbnormal transporter and tight junction protein expression in environmental enteric dysfunction
Abtahi S, Sailer A, Sadiq K, Iqbal N, Ahmed K, Kabir F, Ali S, Turner J. Abnormal transporter and tight junction protein expression in environmental enteric dysfunction. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5615.Peer-Reviewed Original ResearchEnvironmental enteric dysfunctionClaudin-4 expressionTight junction proteinsEnteric dysfunctionBarrier dysfunctionTight junction protein expressionJunction proteinsJunction protein expressionCeliac disease patientsExpression of occludinAbsorption of glucoseNon-celiac patientsFurther studiesTight junction barrier functionEED patientsIntraepithelial lymphocytosisDuodenal biopsiesVillous atrophyDisease patientsIntestinal permeabilityHealthy controlsOccludin expressionIrreversible deficitsMalabsorptionBarrier lossIncidental Ovarian and Uterine Findings on Cross-sectional Imaging
Revzin MV, Sailer A, Moshiri M. Incidental Ovarian and Uterine Findings on Cross-sectional Imaging. Radiologic Clinics Of North America 2021, 59: 661-692. PMID: 34053612, DOI: 10.1016/j.rcl.2021.03.013.Peer-Reviewed Original ResearchConceptsUterine findingsCross-sectional imaging examinationsIncidental adnexal massesBenign ovarian cystsCross-sectional imagingPostmenopausal womenOvarian cystsSurgical interventionGynecologic disordersAdnexal massesUnnecessary imagingIncidental findingImaging examinationsDisordersImagingManagement recommendationsFindingsIncidentalomasHigh frequencyCystsDiagnosisTransportal Chemoembolization as Salvage Hepatocellular Carcinoma Therapy to Maintain Liver Transplant Candidacy.
Tasse JC, Sailer A, Jakate S, Arslan B. Transportal Chemoembolization as Salvage Hepatocellular Carcinoma Therapy to Maintain Liver Transplant Candidacy. Journal Of Vascular And Interventional Radiology : JVIR 2019, 30: 1651-1654.e1. PMID: 31171398, DOI: 10.1016/j.jvir.2019.03.015.Peer-Reviewed Original Research
2023
Intestinal Epithelial Digestive, Transport, and Barrier Protein Expression Is Increased in Environmental Enteric Dysfunction
Abtahi S, Sailer A, Roland J, Haest X, Chanez-Paredes S, Ahmad K, Sadiq K, Iqbal N, Ali S, Turner J. Intestinal Epithelial Digestive, Transport, and Barrier Protein Expression Is Increased in Environmental Enteric Dysfunction. Laboratory Investigation 2023, 103: 100036. PMID: 36870290, PMCID: PMC10121737, DOI: 10.1016/j.labinv.2022.100036.Peer-Reviewed Original Research
2022
Emergency room imaging findings in patients presenting after COVID-19 vaccination
Solomon N, Sailer A, Patel A, Revzin MV. Emergency room imaging findings in patients presenting after COVID-19 vaccination. Journal Of Clinical Imaging Science 2022, 12: 33. PMID: 35769091, PMCID: PMC9235420, DOI: 10.25259/jcis_44_2022.Peer-Reviewed Original ResearchCOVID-19 vaccinationShortness of breathChest painSide effectsCommon presenting signs/symptomsRecent COVID-19 vaccinationVaccine-related complicationsCommon presenting symptomVertebral artery occlusionSigns/symptomsChest X-rayEmergency room patientsCOVID-19 vaccinePotential side effectsMagnetic resonance imagingInstitutional review boardSaddle embolusPresenting symptomVascular complicationsArtery occlusionAxillary adenopathyPrompt diagnosisVascular findingsChief complaintClinical presentation
2019
Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease
Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Laboratory Investigation 2019, 100: 483-490. PMID: 31605016, PMCID: PMC7047618, DOI: 10.1038/s41374-019-0324-8.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInflammatory bowel diseaseClaudin-15 expressionCeliac diseaseMalabsorptive diseaseClaudin-2 expressionClaudin-2Claudin-15Host diseaseDuodenal biopsiesBowel diseaseVariable immunodeficiencyHealthy childrenHealthy controlsNutrient cotransportPostnatal developmentGVHDDiseaseSpecific claudinsQuantitative immunofluorescence microscopyAdultsChildrenImmunofluorescence microscopyDifferential regulationExpression changes
2018
The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. Journal Of Biological Chemistry 2018, 293: 17317-17335. PMID: 30242130, PMCID: PMC6231134, DOI: 10.1074/jbc.ra118.003908.Peer-Reviewed Original ResearchConceptsActin-binding regionZO-2Apical surfaceF-actinOrganization of microvilliCortical F-actinZonula occludens-1F-actin disruptionZO-1 interactionCultured epithelial cellsMembrane trafficGUK domainApical specializationsApical epithelial surfacePDZ1 domainPolarized epitheliumEpithelial organizationActomyosin contractionApical structuresProtein ZO-1Tissue organizationActomyosin functionDevelopmental stagesProtein zonula occludens-1Direct interactionEnvironmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1577-1584. PMID: 29611507, PMCID: PMC6086170, DOI: 10.4269/ajtmh.17-0306.Peer-Reviewed Original ResearchConceptsCeliac diseaseUnderwent upper endoscopyB cell aggregatesHost disease patientsUse therapeutic foodAge-matched specimensResource-poor countriesT lymphocytosisIntraepithelial lymphocytosisDuodenal biopsiesUpper endoscopyVillous atrophyLymphocytic activationEnvironmental enteropathyImmunological featuresDisease patientsMalnourished infantsHealthy controlsNutritional supplementationNutrition interventionsT lymphocytesLamina propriaInsufficient responseTherapeutic foodBirth cohort
2017
Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia
Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine 2017, 22: 191-199. PMID: 28750860, PMCID: PMC5552244, DOI: 10.1016/j.ebiom.2017.07.017.Peer-Reviewed Original ResearchConceptsSevere acute malnutritionHealthy childrenVillus heightIntestinal barrier failureImpaired barrier functionBacterial translocationImmune dysregulationIntestinal damageIntestinal secretionPersistent diarrheaAcute malnutritionAutoantibody generationHistological lesionsMalnourished childrenTranslocation markersCrypt depthNormal rangeHealthy adultsIgG concentrationsClaudin-4Adult controlsAnalysis of markersBarrier functionMalnutritionEpithelial surfaceSa2067 Environmental Enteropathy in Pakistani Children: Clinical Profile and Histomorphometric Analysis
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Qureshi S, Moore S, Turner J, Ali A. Sa2067 Environmental Enteropathy in Pakistani Children: Clinical Profile and Histomorphometric Analysis. Gastroenterology 2017, 152: s437-s438. DOI: 10.1016/s0016-5085(17)31677-3.Peer-Reviewed Original Research