Organ cross talk modulates pelvic pain
Rudick CN, Chen MC, Mongiu AK, Klumpp DJ. Organ cross talk modulates pelvic pain. AJP Regulatory Integrative And Comparative Physiology 2007, 293: r1191-r1198. PMID: 17626130, DOI: 10.1152/ajpregu.00411.2007.Peer-Reviewed Original ResearchConceptsPelvic painInterstitial cystitisLidocaine instillationNeurogenic cystitisCystitis modelPseudorabies virusVascular permeabilityChronic bladder inflammatory diseaseMurine neurogenic cystitis modelVon Frey filament stimulationOrgan cross talkPelvic pain behaviorPelvic pain symptomsProgressive pelvic painMarkers of inflammationIC symptomsPain symptomsVisceral inputsPain behaviorPain responseUnknown etiologySubthreshold doseColon histologyInflammatory diseasesUrothelial lesions