2024
Abstract 971: Validation of a tumor-naïve circulating tumor DNA (ctDNA) response monitoring panel in advanced non-small cell lung cancer (aNSCLC)
Chiang A, Madison R, Huang Y, Fine A, Jin D, Oxnard G, Hughes J, Assaf Z, Cao Y, Antic V, Gjoerup O, Young A, Fabrizio D, Lakhanpal S, Zuniga R, Schulze K, Pasquina L. Abstract 971: Validation of a tumor-naïve circulating tumor DNA (ctDNA) response monitoring panel in advanced non-small cell lung cancer (aNSCLC). Cancer Research 2024, 84: 971-971. DOI: 10.1158/1538-7445.am2024-971.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerPeripheral blood mononuclear cellsNon-small cell lung cancerRisk of progressionCell lung cancerClonal hematopoiesisTumor fractionGenomic alterationsTumor signalAmerican Association for Cancer Research annual meetingsLung cancerHazard ratioPatient's risk of progressionFrequency of genomic alterationsAssociated with favorable outcomesMolecular responseWeeks of TxProgression free survivalUnivariate Cox proportional hazards regressionCox proportional hazards regressionBlood mononuclear cellsConfidence intervalsVariant allele frequencyCombination of aneuploidyProportional hazards regression
2023
Differential Effect of Consolidative Thoracic Radiation Therapy in Extensive-Stage Small Cell Lung Cancer Based on Sex
Jairam V, Soulos P, Madhav K, Gross C, Slotman B, Chiang A, Park H. Differential Effect of Consolidative Thoracic Radiation Therapy in Extensive-Stage Small Cell Lung Cancer Based on Sex. Advances In Radiation Oncology 2023, 9: 101413. PMID: 38778819, PMCID: PMC11110031, DOI: 10.1016/j.adro.2023.101413.Peer-Reviewed Original ResearchExtensive-stage small-cell lung cancerConsolidative thoracic radiotherapyProgression-free survivalSmall cell lung cancerCell lung cancerCREST trialThoracic radiotherapyLung cancerElectronic health record-derived databaseFirst-line systemic therapyStandard first-line treatmentCox proportional hazards regressionFirst-line treatmentNational practice patternsProportional hazards regressionSuperior OSInitial chemotherapyBaseline characteristicsSystemic therapyMale patientsFemale patientsPatient sexHazards regressionSurvival outcomesPractice patterns