2012
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
Abyzov A, Mariani J, Palejev D, Zhang Y, Haney MS, Tomasini L, Ferrandino AF, Rosenberg Belmaker LA, Szekely A, Wilson M, Kocabas A, Calixto NE, Grigorenko EL, Huttner A, Chawarska K, Weissman S, Urban AE, Gerstein M, Vaccarino FM. Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature 2012, 492: 438-442. PMID: 23160490, PMCID: PMC3532053, DOI: 10.1038/nature11629.Peer-Reviewed Original Research
2005
Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage
Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Nasr A, Canaan A, Weissman SM. Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage. Molecular And Cellular Biology 2005, 25: 10492-10506. PMID: 16287861, PMCID: PMC1291253, DOI: 10.1128/mcb.25.23.10492-10506.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesCell ProliferationCells, CulturedCellular SenescenceDNADNA DamageDNA HelicasesDNA ReplicationExodeoxyribonucleasesFibroblastsGene Expression RegulationHumansOxidation-ReductionOxidative StressOxygenRecQ HelicasesRNA InterferenceTelomeric Repeat Binding Protein 2Werner Syndrome HelicaseConceptsDNA damage responseWerner syndromeDamage responseDNA damageRNA interferenceOxidative DNA damageWRN-depleted cellsInduction of gammaH2AXDNA damage fociCellular senescence phenotypePrimary human fibroblastsWRN depletionWerner proteinWRN proteinNuclear fociWRN deficiencyProtein TRF2Telomere maintenanceAcute oxidative stressBLM expressionDNA homeostasisDNA replicationDamage fociSenescence phenotypePhysiological oxygen