2005
Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage
Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Nasr A, Canaan A, Weissman SM. Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage. Molecular And Cellular Biology 2005, 25: 10492-10506. PMID: 16287861, PMCID: PMC1291253, DOI: 10.1128/mcb.25.23.10492-10506.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesCell ProliferationCells, CulturedCellular SenescenceDNADNA DamageDNA HelicasesDNA ReplicationExodeoxyribonucleasesFibroblastsGene Expression RegulationHumansOxidation-ReductionOxidative StressOxygenRecQ HelicasesRNA InterferenceTelomeric Repeat Binding Protein 2Werner Syndrome HelicaseConceptsDNA damage responseWerner syndromeDamage responseDNA damageRNA interferenceOxidative DNA damageWRN-depleted cellsInduction of gammaH2AXDNA damage fociCellular senescence phenotypePrimary human fibroblastsWRN depletionWerner proteinWRN proteinNuclear fociWRN deficiencyProtein TRF2Telomere maintenanceAcute oxidative stressBLM expressionDNA homeostasisDNA replicationDamage fociSenescence phenotypePhysiological oxygen
2000
Werner protein recruits DNA polymerase δ to the nucleolus
Szekely A, Chen Y, Zhang C, Oshima J, Weissman S. Werner protein recruits DNA polymerase δ to the nucleolus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11365-11370. PMID: 11027336, PMCID: PMC17206, DOI: 10.1073/pnas.97.21.11365.Peer-Reviewed Original ResearchConceptsWerner proteinWRN proteinDNA replicationPolymerase deltaChromosomal DNA replicationTwo-hybrid screeningSubcellular localization studiesDNA polymerase δMajor DNA polymeraseDNA helicasesRecQ familyDNA transactionsDynamic relocalizationNucleolar proteinsCatalytic subunitPolymerase δC-terminusWRN geneWerner syndromeExonuclease activityPhysiological functionsMendelian disordersLocalization studiesLines of evidenceDNA polymerase