2022
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity 2022, 55: 1082-1095.e5. PMID: 35588739, PMCID: PMC9205175, DOI: 10.1016/j.immuni.2022.04.015.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsAnti-inflammatory propertiesMyeloid cellsPrescription nonsteroidal anti-inflammatory drugsGrowth/differentiation factor 15Anti-inflammatory effectsDifferentiation factor 15Myeloid-specific deletionAnti-inflammatory activityAnti-inflammatory drugsNrf2-dependent mechanismKelch-like ECHTranscription factor Nrf2NSAID usageClinical outcomesCOX inhibitionPharmacologic approachesFactor 15Murine modelTissue protectionMurine myeloid cellsNuclear factorPrimary humanFactor Nrf2Nrf2
2020
Food Allergy: Searching for the Modern Environmental Culprit.
Eisenstein AS, Hilliard B, Silwal S, Wang A. Food Allergy: Searching for the Modern Environmental Culprit. The Yale Journal Of Biology And Medicine 2020, 93: 733-747. PMID: 33380935, PMCID: PMC7757057.Peer-Reviewed Original ResearchBone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis
Eisenstein A, Chitalia S, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. International Journal Of Molecular Sciences 2020, 21: 7470. PMID: 33050467, PMCID: PMC7589187, DOI: 10.3390/ijms21207470.Peer-Reviewed Original ResearchConceptsBone healthBone marrowPotential therapeutic targetInhibitory receptorsMetabolic disturbancesReceptor effectsTherapeutic implicationsTherapeutic targetMetabolic diseasesEndogenous ligandDichotomous effectsReceptorsMarrowAdenosineAdipogenesisExpression profilesCellular stressHealthOsteogenesisCurrent understandingDifferent tissuesObesityInflammationDisease
2018
Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions
Eisenstein A, Panova IP, Chung HJ, Goldberg LJ, Zhang Q, Lazova R, Bhawan J, Busam KJ, Symanowski JT, Alani RM, Ryu B. Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions. Melanoma Research 2018, 28: 71-75. PMID: 29227334, PMCID: PMC5805139, DOI: 10.1097/cmr.0000000000000416.Peer-Reviewed Original Research
2015
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases
Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Journal Of Cellular Physiology 2015, 230: 2891-2897. PMID: 25975415, PMCID: PMC4811601, DOI: 10.1002/jcp.25043.Peer-Reviewed Original Research
2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activationThe Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammationIntegration of Basic Science and Clinical Medicine
Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O’Hara C, Joseph L. Integration of Basic Science and Clinical Medicine. Academic Medicine 2014, 89: 50-53. PMID: 24280854, DOI: 10.1097/acm.0000000000000054.Peer-Reviewed Original ResearchMeSH KeywordsAnatomyBiological Science DisciplinesBiopsyBostonCadaverClinical CompetenceCurriculumEducation, Medical, UndergraduateEducational MeasurementEvidence-Based MedicineHistologyHumansModels, EducationalOrganizational InnovationPathologyProgram DevelopmentProgram EvaluationRadiologySchools, MedicalStudents, MedicalConceptsMedical education reformStudents' first experiencesCase-based learningMedical education initiativesCompetency-based outcomesEducation reformBoston University School of MedicineScience contentIntegrated curriculumCurricular innovationsCurricular designCurricular integrationStu-dentsScience coursesSenior medical studentsIntegration of topicsGross anatomy courseEducational initiativesTest scoresMedical stu-dentsEducational interventionAnatomy courseAcquired skillsPatient careStudents
2013
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein A, Ravid K. G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors. Journal Of Cellular Physiology 2013, 229: 414-421. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsAdenosine receptorsExtracellular signalsAdenosine signalingObesity epidemicMetabolic consequencesDevelopment of therapeuticsBlood flowDownstream messengersReceptorsTranscriptional eventsAdipose tissueMature adipocytesAdipocyte differentiationCellular differentiationMetabolic homeostasisAdenosineCoupled receptorsAdipocytesPhysiological outcomesDifferentiation processExcess nutrientsRegulation functionAdipogenesisDifferentiation
2012
A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a
2010
Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival
Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. Journal Of Clinical Oncology 2010, 28: 3958-3964. PMID: 20679621, PMCID: PMC2940394, DOI: 10.1200/jco.2009.27.0793.Peer-Reviewed Original ResearchConceptsBody mass indexPCa-specific mortalityTimes higher riskProstate cancer riskFatty acid synthaseLethal PCaPCa mortalityOverweight patientsLean menOverweight menMass indexTumor expressionSingle nucleotide polymorphismsCancer riskHigh riskFASN expressionHigher body mass indexVariant allelesPCa-specific deathCase-control studyAge-matched controlsGermline single nucleotide polymorphismsCommon germline single nucleotide polymorphismsDe novo lipogenesisHomozygous variant allele