2022
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity 2022, 55: 1082-1095.e5. PMID: 35588739, PMCID: PMC9205175, DOI: 10.1016/j.immuni.2022.04.015.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsAnti-inflammatory propertiesMyeloid cellsPrescription nonsteroidal anti-inflammatory drugsGrowth/differentiation factor 15Anti-inflammatory effectsDifferentiation factor 15Myeloid-specific deletionAnti-inflammatory activityAnti-inflammatory drugsNrf2-dependent mechanismKelch-like ECHTranscription factor Nrf2NSAID usageClinical outcomesCOX inhibitionPharmacologic approachesFactor 15Murine modelTissue protectionMurine myeloid cellsNuclear factorPrimary humanFactor Nrf2Nrf2
2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activationThe Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammation
2012
A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a