The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternHumansInsulin ResistanceMacrophagesMaleMiceMice, TransgenicPolymerase Chain ReactionReceptor, Adenosine A2BTumor Necrosis Factor-alphaConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammation