Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival
Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. Journal Of Clinical Oncology 2010, 28: 3958-3964. PMID: 20679621, PMCID: PMC2940394, DOI: 10.1200/jco.2009.27.0793.Peer-Reviewed Original ResearchConceptsBody mass indexPCa-specific mortalityTimes higher riskProstate cancer riskFatty acid synthaseLethal PCaPCa mortalityOverweight patientsLean menOverweight menMass indexTumor expressionSingle nucleotide polymorphismsCancer riskHigh riskFASN expressionHigher body mass indexVariant allelesPCa-specific deathCase-control studyAge-matched controlsGermline single nucleotide polymorphismsCommon germline single nucleotide polymorphismsDe novo lipogenesisHomozygous variant allele