2015
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases
Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Journal Of Cellular Physiology 2015, 230: 2891-2897. PMID: 25975415, PMCID: PMC4811601, DOI: 10.1002/jcp.25043.Peer-Reviewed Original Research
2014
The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammation
2013
A2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4
Eisenstein A, Ravid K. A2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4. The FASEB Journal 2013, 27: 599.1-599.1. DOI: 10.1096/fasebj.27.1_supplement.599.1.Peer-Reviewed Original ResearchIn vivo BrdU labelingA2BAR KO miceBay 60-6583A2B adenosine receptorsStem cell factorWild type miceAdipocyte differentiationHigh-fat diet feedingActivate adenylyl cyclaseA2BAR signalingAssociated with cellular proliferationFat diet feedingAdenosine signalingKO miceType miceSpecific agonistsStromal vascular fractionStem cell fateCell factorAdenosine receptorsInhibited adipocyte differentiationPrecursor proliferationA2BARAdenylyl cyclaseMesenchymal stem cells