A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a