2024
Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination
Vesco K, Denoble A, Lipkind H, Kharbanda E, DeSilva M, Daley M, Getahun D, Zerbo O, Naleway A, Jackson L, Williams J, Boyce T, Fuller C, Weintraub E, Vazquez-Benitez G. Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination. Obstetrics And Gynecology 2024, 143: 794-802. PMID: 38626447, PMCID: PMC11090513, DOI: 10.1097/aog.0000000000005583.Peer-Reviewed Original ResearchConceptsSmall-for-gestational ageMessenger RNA COVID-19 vaccineGestational diabetes mellitusRisk of adverse pregnancy outcomesAdverse pregnancy outcomesPreterm birthGestational hypertensionAdjusted hazard ratiosCOVID-19 vaccine dosesPregnancy outcomesCOVID-19 vaccineAssociated with small-for-gestational ageIncreased risk of adverse pregnancy outcomesVaccine doseRisk of preterm birthMessenger RNARetrospective cohort study of individualsMRNA COVID-19 vaccineWeeks of gestationRetrospective cohort studyHistory of COVID-19Cohort study of individualsVaccine Safety DatalinkSingleton pregnanciesUnexposed pregnanciesRate of clinically significant red blood cell antibody seroconversion in pregnancy
Ding J, Abels E, Jacobs J, Culhane J, Lundsberg L, Partridge C, Denoble A, Kohari K. Rate of clinically significant red blood cell antibody seroconversion in pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2419370. PMID: 39462637, DOI: 10.1080/14767058.2024.2419370.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitAdvanced maternal ageAssociated with seroconversionClinically significant antibodiesAntibody screeningNeonatal outcomesIncreasing gravidityAntibody seroconversionInitial hemoglobinMaternal ageSignificant antibodiesAntibody statusNeonatal intensive care unit admissionCohort studyClinically significant RBC antibodiesAnti-CUnexplained fetal lossPositive antibody screenNegative antibody screenCases of stillbirthRetrospective cohort studyIntensive care unitWilcoxon rank-sumMaternal antibody statusPostnatal transfusion
2023
Hypertension Screening in Pregnancy
Denoble A, Pettker C. Hypertension Screening in Pregnancy. JAMA 2023, 330: 1040-1041. PMID: 37721621, DOI: 10.1001/jama.2023.15088.Commentaries, Editorials and LettersAntihypertensives in Pregnancy
Denoble A, Goldstein S, Pettker C. Antihypertensives in Pregnancy. Obstetrics And Gynecology Clinics Of North America 2023, 50: 39-78. PMID: 36822710, DOI: 10.1016/j.ogc.2022.10.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSignificant maternal morbidityTreatment of hypertensionAmniotic fluid volumeHypertensive disordersMaternal morbidityPregnant patientsFetal growthCurrent guidelinesEfficacy dataAvailable safetyPregnancyAntihypertensivesFluid volumeClose supervisionHypertensionMorbidityPatientsPostpartumMortalityAvailable dataDiagnosis
2022
Prospective Observational Study of N-terminal Pro–Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy
Denoble A, Moyett J, Goldstein S, Ward CC, Truong T, Erkanli A, James A, Grotegut C. Prospective Observational Study of N-terminal Pro–Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy. American Journal Of Perinatology 2022, 40: 467-474. PMID: 35973801, PMCID: PMC10168705, DOI: 10.1055/a-1925-1532.Peer-Reviewed Original ResearchConceptsNT-proBNP levelsBody mass indexProspective observational studyObese patientsNonobese patientsNT-proBNPWeeks postpartumObservational studyN-terminal pro-brain natriuretic peptide levelsN-terminal pro-brain natriuretic peptidePro-brain natriuretic peptide levelsLinear mixed effects modelsLower NT-proBNP levelsHigher systolic blood pressurePro-brain natriuretic peptidePregnant peopleNatriuretic peptide levelsSignificant medical comorbiditiesTime pointsSystolic blood pressureMixed effects modelsEffects modelLogNT-proBNPPP elevationHypertensive disordersComparison of severe maternal morbidity in pregnancy by modified World Health Organization Classification of maternal cardiovascular risk
Denoble AE, Goldstein SA, Wein LE, Grotegut CA, Federspiel JJ. Comparison of severe maternal morbidity in pregnancy by modified World Health Organization Classification of maternal cardiovascular risk. American Heart Journal 2022, 250: 11-22. PMID: 35526569, PMCID: PMC9836743, DOI: 10.1016/j.ahj.2022.04.009.Peer-Reviewed Original ResearchConceptsSevere maternal morbidityWorld Health Organization classificationDelivery hospitalizationsCardiac diagnosisMaternal morbidityOrganization classificationMaternal cardiovascular riskNationwide Readmissions DatabaseRisk of deathSevere cardiac diseaseWeighted national estimateMWHO classificationDelivery admissionCardiovascular riskPregnant patientsSecondary outcomesPrimary outcomeRetrospective studyYear postpartumPregnancy counselingPrimary exposureMonths postpartumNationwide databaseCardiac diseaseElevated risk
2021
Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1C
Dillon J, Mitchell CJ, Ellett T, Siegel A, Denoble AE, Dotters-Katz SK. Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1C. American Journal Of Perinatology 2021, 39: 238-242. PMID: 34891200, DOI: 10.1055/s-0041-1739358.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusClass III obesityBody mass indexPre-diabetic rangeGestational diabetesA1C 5.7Normal A1CPrimary outcomeGestational ageDevelopment of GDMClass III obese womenDelivery body mass indexNon-anomalous singleton pregnanciesMaternal body mass indexLow-A1C groupFetal growth restrictionInduction of laborHigh-risk populationA1c groupMedian A1CPregnancy complicationsBaseline demographicsCesarean deliveryMultiple gestationsObese womenManagement of Cerclage in Patients With Preterm Prelabor Rupture of Membranes
Wu J, Denoble AE, Kuller JA, Dotters-Katz SK. Management of Cerclage in Patients With Preterm Prelabor Rupture of Membranes. Obstetrical & Gynecological Survey 2021, 76: 681-691. PMID: 34854925, DOI: 10.1097/ogx.0000000000000957.Peer-Reviewed Original ResearchConceptsMaternal infectious morbidityPreterm prelabor ruptureCerclage removalCervical cerclageInfectious morbidityNeonatal outcomesPrelabor ruptureNeonatal morbidity outcomesRetention of cerclageSetting of PPROMTime of PPROMTime of diagnosisCerclage placementCerclage retentionLatency antibioticsNeonatal complicationsCorticosteroid administrationMaternal morbidityPreterm laborNeonatal sepsisMorbidity outcomesNeonatal mortalityRetrospective natureDefinitive benefitPPROMPregnancy outcomes among women with class III obesity with normal early glucola
Ellett T, Mitchell CJ, Dillon J, Siegel A, Denoble AE, Dotters-Katz S. Pregnancy outcomes among women with class III obesity with normal early glucola. The Journal Of Maternal-Fetal & Neonatal Medicine 2021, 35: 5834-5839. PMID: 33818267, DOI: 10.1080/14767058.2021.1895741.Peer-Reviewed Original ResearchConceptsBody mass indexRate of GDMGlucose challenge testGestational diabetesObese womenPrimary outcomeGestational ageChallenge testDelivery body mass indexNon-anomalous singleton pregnanciesMaternal body mass indexOral glucose challenge testClass 3 obesityDevelopment of GDMClass III obesityGestational diabetes mellitusFetal growth restrictionInduction of laborNeonatal birthweightPregnancy complicationsBaseline demographicsCesarean deliveryMultiple gestationsPregnancy outcomesRetrospective cohort
2020
Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis?
Rosett HA, Krischak MK, Sachdeva S, Weaver KE, Heine RP, Denoble AE, Dotters-Katz SK. Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis? American Journal Of Perinatology 2020, 39: 473-478. PMID: 32971563, DOI: 10.1055/s-0040-1717093.Peer-Reviewed Original ResearchConceptsLower urinary tract infectionsHistory of preeclampsiaPreterm birthPregnant womenLow birthweightPathogenic infectionsOutside of pregnancyRisk of pyelonephritisOdds of progressionSingle tertiary centerPreterm birth rateRisk of progressionUrinary tract infectionBody mass indexRate of progressionHistory of pyelonephritisAsymptomatic bacteriuriaChronic hypertensionMedian LOSObstetric outcomesUrinary culturePostpartum dataRetrospective cohortSecondary outcomesTract infectionsChorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different?
Denoble AE, Wu J, Mitchell CJ, Hughes BL, Dotters-Katz SK. Chorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different? American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100176. PMID: 33345890, DOI: 10.1016/j.ajogmf.2020.100176.Peer-Reviewed Original ResearchConceptsPostpartum infectious morbidityIntraamniotic infectionClinical chorioamnionitisPostpartum endometritisAntibiotic treatmentMaternal temperatureAmerican CollegeInfectious morbidityPreterm deliveryPotential confoundersGynecologists criteriaAdditional clinical risk factorsAntenatal magnesium sulfateIntrapartum antibiotic treatmentPostpartum endometritis ratePostpartum infectious complicationsClinical risk factorsMultivariate logistic regressionOriginal study populationProportion of womenEndometritis ratesFetal morbidityInfectious complicationsPreterm birthPrimary outcomePrenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report
DeNoble AE, Saccoccio FM, Permar SR, Hughes BL. Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report. Clinical Infectious Diseases 2020, 71: 2506-2508. PMID: 32198512, DOI: 10.1093/cid/ciaa305.Peer-Reviewed Original ResearchConceptsCommon congenital infectionCongenital CMV infectionCases of hydropsCongenital cytomegalovirusCongenital infectionCMV infectionNeonatal treatmentNeurologic injuryCCMV infectionInfectious causesCase reportFetal anomaliesPrenatal treatmentTreatment strategiesMinimal sequelaeCytomegalovirusInfectionValganciclovirTreatmentSequelaeHydropsPregnancyInjuryUsing the new definition of intraamniotic infection – is there morbidity among the women left out?
Smith MM, Daifotis HA, DeNoble AE, Dotters-Katz SK. Using the new definition of intraamniotic infection – is there morbidity among the women left out? The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 34: 4148-4152. PMID: 31928262, DOI: 10.1080/14767058.2020.1711723.Peer-Reviewed Original ResearchConceptsPostpartum infectionIntraamniotic infectionPrimary outcomePostpartum infectious morbidityUrinary tract infectionSingle academic centerFourth-degree lacerationsBackward stepwise eliminationACOG criteriaAntibiotic receiptGestational hypertensionIntrapartum characteristicsMaternal feverMaternal tachycardiaDegree lacerationsInfectious morbidityRetrospective cohortTract infectionsDiagnostic criteriaAcademic centersInfectionWomenBivariate statisticsMorbidityFever
2019
Chorioamnionitis and Infectious Complications after Vaginal Delivery
DeNoble AE, Heine RP, Dotters-Katz SK. Chorioamnionitis and Infectious Complications after Vaginal Delivery. American Journal Of Perinatology 2019, 36: 1437-1441. PMID: 31238347, DOI: 10.1055/s-0039-1692718.Peer-Reviewed Original ResearchConceptsBody mass indexPostpartum infectious complicationsPostpartum infectionPostpartum antibioticsInfectious complicationsPreterm deliveryPrimary outcomeVaginal deliveryMaternal-Fetal Medicine Unit Cesarean RegistryPrepregnancy body mass indexSeptic pelvic thrombophlebitisUrinary tract infectionCesarean RegistryEunice KennedyPelvic thrombophlebitisSuccessful VBACTract infectionsMass indexPelvic abscessVaginal birthRisk factorsMultivariate predictorsChild healthMultivariate analysisChorioamnionitisFactors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth
DeNoble AE, Wynn CE, Weaver KE, Wheeler SM, Swamy GK. Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth. American Journal Of Perinatology 2019, 37: 264-270. PMID: 30708392, DOI: 10.1055/s-0039-1678532.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrior term birthPrenatal care initiationEligible womenPreterm birthPrimary outcomeTerm birthsWeeks' gestationCare initiationHispanic ethnicityRecurrent spontaneous preterm birthSingleton spontaneous preterm birthPrior spontaneous preterm birthRecurrent preterm birthRetrospective cohort studyAcademic health systemStepwise logistic regressionSPTB rateCohort studyEligible subjectsSingleton pregnanciesClinical predictorsPoor adherenceMaternal ageCare barriersBeyond the Window: Patient Characteristics and Geographic Locations Associated with Late Prenatal Care in Women Eligible for 17-P Preterm Birth Prevention
Wheeler S, DeNoble A, Wynn C, Weaver K, Swamy G, Janko M, Lantos P. Beyond the Window: Patient Characteristics and Geographic Locations Associated with Late Prenatal Care in Women Eligible for 17-P Preterm Birth Prevention. Journal Of Racial And Ethnic Health Disparities 2019, 6: 563-569. PMID: 30632084, DOI: 10.1007/s40615-018-00555-8.Peer-Reviewed Original ResearchConceptsLate presentationPreterm birthGestational ageSingle academic medical centerPatient-level risk factorsIndex pregnancy outcomeRisk of presentationMean gestational agePreterm birth preventionRetrospective cohort studySpontaneous preterm birthLate prenatal careYoung maternal ageRisk of recurrenceWeeks of pregnancyLater gestational agesEarly prenatal care initiationPrenatal care initiationAcademic medical centerBirth preventionCohort studyCurrent smokingLate presentersPatient characteristicsPregnancy outcomes
2018
Antibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections
DeNoble AE, Kuller JA, Heine RP, Dotters-Katz S. Antibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections. Obstetrical & Gynecological Survey 2018, 73: 475-485. PMID: 30169886, DOI: 10.1097/ogx.0000000000000590.Peer-Reviewed Original ResearchConceptsPostsurgical infectionsObstetric infectionsProphylactic antibioticsCesarean deliverySystematic reviewAvailable evidenceLimited retrospective studyUnlabored cesarean deliveryCornerstone of preventionEvidence-based guidelinesCommon bacterial isolatesEffective antibiotic regimenSecond-generation cephalosporinsAntibiotic resistanceSearch of PubMedAntibiotic selectionFirst-generation cephalosporinsRelevant original research articlesGlobal health threatAdjunctive azithromycinAntibiotic prophylaxisInfectious complicationsMaternal morbidityAntibiotic regimenOperative intervention
2015
Controversies in the Management of Isolated Congenital Atrioventricular Block
DeNoble AE, Kuller JA, Rhee EJ. Controversies in the Management of Isolated Congenital Atrioventricular Block. Obstetrical & Gynecological Survey 2015, 70: 518-523. PMID: 26314237, DOI: 10.1097/ogx.0000000000000208.Peer-Reviewed Original ResearchConceptsCongenital atrioventricular blockAnti-La antibodiesAtrioventricular blockIntravenous immunoglobulinFetuses of mothersStudy of dexamethasoneTreatment of fetusesLarge prospective studiesHigh fetal morbidityPotential adverse effectsRheumatologic symptomsAnti-RoFetal morbidityAntinuclear antibodiesFetal hydropsProspective studyTreatment regimensAutoimmune diseasesRisk mothersLimited potential benefitsAdverse effectsFetusesConflicting resultsAntibodiesTreatment
2014
Receipt of Prescription Contraception by Commercially Insured Women With Chronic Medical Conditions
DeNoble AE, Hall KS, Xu X, Zochowski MK, Piehl K, Dalton VK. Receipt of Prescription Contraception by Commercially Insured Women With Chronic Medical Conditions. Obstetrics And Gynecology 2014, 123: 1213-1220. PMID: 24807345, PMCID: PMC4169713, DOI: 10.1097/aog.0000000000000279.Peer-Reviewed Original ResearchConceptsChronic medical conditionsPrescription contraceptionChronic conditionsMedical conditionsCommunity-level socioeconomic statusAdministrative claims recordsTotal outpatient visitsInflammatory bowel diseaseSystemic lupus erythematosusCervical cancer screeningMultivariable logistic regressionChronic condition statusBowel diseaseLupus erythematosusOrder of prevalencePharmacy claimsPrimary outcomeOutpatient visitsRheumatoid arthritisAdverse outcomesCancer screeningUnplanned pregnancyObservational studyStudy populationInsured women
2011
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VB. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2088-2093. PMID: 21245324, PMCID: PMC3033282, DOI: 10.1073/pnas.1012743108.Peer-Reviewed Original ResearchConceptsIL-18OA severityIL-1βUric acidOA progressionSynovial fluid IL-1βCohort of subjectsKnee OA severityInnate immune systemKnee osteoarthritisBone scintigraphyNLRP3 inflammasomeOA pathologyInflammasome activationDanger signalsImmune systemOsteoarthritisRadiographsSeverityPotential involvementInflammasomeProgressionScintigraphyNLRP3Cytokines