Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VB. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2088-2093. PMID: 21245324, PMCID: PMC3033282, DOI: 10.1073/pnas.1012743108.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarrier ProteinsCohort StudiesFemaleHumansInterleukin-1Interleukin-18KneeMaleMiddle AgedNLR Family, Pyrin Domain-Containing 3 ProteinOsteoarthritisRisk FactorsSeverity of Illness IndexUric AcidConceptsIL-18OA severityIL-1βUric acidOA progressionSynovial fluid IL-1βCohort of subjectsKnee OA severityInnate immune systemKnee osteoarthritisBone scintigraphyNLRP3 inflammasomeOA pathologyInflammasome activationDanger signalsImmune systemOsteoarthritisRadiographsSeverityPotential involvementInflammasomeProgressionScintigraphyNLRP3Cytokines