2019
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis
Wingrove E, Liu ZZ, Patel KD, Arnal-Estapé A, Cai WL, Melnick MA, Politi K, Monteiro C, Zhu L, Valiente M, Kluger HM, Chiang VL, Nguyen DX. Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. Cell Reports 2019, 27: 1277-1292.e7. PMID: 31018140, PMCID: PMC6592283, DOI: 10.1016/j.celrep.2019.03.085.Peer-Reviewed Original ResearchConceptsBrain metastasesBrain tumor microenvironmentLineage programTumor microenvironmentTumor plasticityStromal gene expressionTranscriptomic hallmarksGene expressionTranscriptional hallmarksMultiple tumor typesMolecular landscapeStromal interactionsMajor siteIntact tissueNeuroinflammatory responseSyngeneic modelPatient biopsiesTumor typesMetastasisMalignant cellsDifferent subtypesTumor cellsHallmarkTranscriptomeCells
2015
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun M, Maryanovich M, Arnal-Estapé A, Frenette P. Neural Regulation of Hematopoiesis, Inflammation, and Cancer. Neuron 2015, 86: 360-373. PMID: 25905810, PMCID: PMC4416657, DOI: 10.1016/j.neuron.2015.01.026.Peer-Reviewed Original ResearchConceptsAutonomic nervous systemStem cell niche homeostasisRegulation of hematopoiesisStromal constituentsHematopoietic homeostasisHematopoietic systemTherapeutic strategiesInflammatory responseNiche homeostasisCancer cellsNeural regulationFlight-or-fight responsePeripheral innervationNervous systemCancerNeural circuitryRegulate cell behaviorInflammationHomeostasisCell behaviorHematopoiesisInnervationResponseMicroenvironment