2019
In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease
Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD. In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease. Blood Advances 2019, 3: 2082-2092. PMID: 31296496, PMCID: PMC6650737, DOI: 10.1182/bloodadvances.2019000227.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCD11c AntigenCell CommunicationDendritic CellsDisease Models, AnimalFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility Antigens Class IImmunophenotypingLymphocyte DepletionMiceMice, TransgenicProtein BindingReceptors, Antigen, T-CellSkin DiseasesT-Lymphocyte SubsetsT-LymphocytesTransplantation, HomologousConceptsDonor dendritic cellsCD8 cellsT cellsGVHD lesionsHost diseaseCD4 cellsDendritic cellsAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationMajority of CD4Dynamics of CD4Stem cell transplantationCutaneous graftAntibody infusionCell transplantationMyeloid cellsIntravital microscopyAcute deletionMajor causeLesionsTarget tissuesCD103CD4InfusionMHCIIGerminal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches
Haberman AM, Gonzalez DG, Wong P, Zhang T, Kerfoot SM. Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches. Immunological Reviews 2019, 288: 10-27. PMID: 30874342, PMCID: PMC10234181, DOI: 10.1111/imr.12731.Peer-Reviewed Original Research
2017
Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help
Zhang TT, Gonzalez DG, Cote CM, Kerfoot SM, Deng S, Cheng Y, Magari M, Haberman AM. Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help. ELife 2017, 6: e19552. PMID: 28498098, PMCID: PMC5429091, DOI: 10.7554/elife.19552.Peer-Reviewed Original Research
2012
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, Ferrandino AF, Gonzalez D, Habermann A, Flavell RA, Fahmy TM. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nature Materials 2012, 11: 895-905. PMID: 22797827, PMCID: PMC3601683, DOI: 10.1038/nmat3355.Peer-Reviewed Original ResearchConceptsInterleukin-2TGF-β inhibitorTumor microenvironmentImmune responseLocal tumor immune responseMultiple immunologic mechanismsT cell infiltrationNatural killer cellsTumor immune responseAdaptive immune responsesTumor-bearing miceImmunotherapy resultsConventional immunotherapyImmunologic mechanismsKiller cellsTumor immunotherapyMetastatic melanomaConventional cytokinesProtein cytokinesHigh dosesTumor growthGrowth factorMolecular inhibitorsCombination deliveryImmunotherapy
2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
Lee HK, Zamora M, Linehan MM, Iijima N, Gonzalez D, Haberman A, Iwasaki A. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. Journal Of Experimental Medicine 2009, 206: 359-370. PMID: 19153243, PMCID: PMC2646574, DOI: 10.1084/jem.20080601.Peer-Reviewed Original ResearchConceptsResident dendritic cellsCD8 T cellsDendritic cellsHSV-1 infectionT cellsEpicutaneous infectionAntigen presentationLymph node-resident dendritic cellsHSV-specific T cellsCD4 T cell responsesNeedle injectionHerpes simplex virus 1 (HSV-1) infectionSimplex virus 1 infectionT cell primingT cell responsesVirus-1 infectionMode of infectionDC populationsCell primingVaginal infectionsImmune responseMucosal tissuesMucosal surfacesHSV-1Cell responses
2002
Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced
Dal Porto JM, Haberman AM, Kelsoe G, Shlomchik MJ. Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced. Journal Of Experimental Medicine 2002, 195: 1215-1221. PMID: 11994427, PMCID: PMC2193705, DOI: 10.1084/jem.20011550.Peer-Reviewed Original ResearchConceptsAntibody-forming cellsMemory B cellsImmune responseB cellsB cell antigen receptorT cell-dependent immune responsesCell-dependent immune responsesLow-affinity B cellsH chain transgenic miceMemory B cell populationsHigh affinity competitionSecondary immune responseSpecific immune responseAntigen-specific cellsGerminal center responseSuch B cellsB cell populationsH chain transgeneLate primary responseGerminal centersTransgenic miceCenter responseCell antigen receptorAntigen receptorPrimary response
1999
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
Chan O, Hannum L, Haberman A, Madaio M, Shlomchik M. A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. Journal Of Experimental Medicine 1999, 189: 1639-1648. PMID: 10330443, PMCID: PMC2193634, DOI: 10.1084/jem.189.10.1639.Peer-Reviewed Original ResearchConceptsB cellsAutoantibody productionMRL/MpJ-Faslpr miceAutoreactive T cellsAntigen-presenting cellsAntibody-independent roleB cell functionFunctional B cellsExpression of diseaseSerum autoantibodiesMurine lupusLocal inflammationSystemic autoimmunitySerum antibodiesPathogenic roleAntigen presentationT cellsCellular infiltrationSurface immunoglobulinPathologic phenotypeDisease expressionCell functionMiceNovel mousePrecise role