2022
Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchMeSH KeywordsAppetiteCerebrovascular CirculationGlucocorticoidsHumansHungerHydrocortisoneInsulinMagnetic Resonance ImagingConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2016
Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
Jastreboff AM, Sinha R, Arora J, Giannini C, Kubat J, Malik S, Van Name MA, Santoro N, Savoye M, Duran EJ, Pierpont B, Cline G, Constable RT, Sherwin RS, Caprio S. Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 2016, 65: 1929-1939. PMID: 27207544, PMCID: PMC5384636, DOI: 10.2337/db15-1216.Peer-Reviewed Original ResearchConceptsObese adolescentsLean adolescentsGlucose ingestionInsulin levelsBrain perfusionBrain regionsSugar-sweetened beverage consumptionAltered brain responsesHedonic brain regionsHippocampal blood flowFurther weight gainFructose ingestionAcyl ghrelinAttenuated suppressionFructose consumptionPerfusion responseBlood flowBrain adaptationBeverage consumptionGreater perfusionPerfusionVentral striatumFunctional MRIWeight gainIngestionFunctional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers
Garrison KA, Sinha R, Lacadie CM, Scheinost D, Jastreboff AM, Constable RT, Potenza MN. Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers. Nicotine & Tobacco Research 2016, 18: 1820-1829. PMID: 26995796, PMCID: PMC4978981, DOI: 10.1093/ntr/ntw088.Peer-Reviewed Original ResearchConceptsFunctional connectivityBrain regionsSupramarginal gyrusFavorite-food cuesSmoking-related alterationsMagnetic resonance imaging studyBrain functional connectivity patternsPrevious functional magnetic resonance imaging (fMRI) studiesTobacco use disorderBrain networksIntrinsic connectivity distributionResonance imaging studyFunctional magnetic resonance imaging studyFunctional connectivity patternsMultiple brain networksSmoking cessationNonsmokersPosterior insulaRolandic operculumSmokersFunctional brain networksImaging studiesGreater connectivityNeural responsesRecent reports
2014
Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity
Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity. Diabetes Care 2014, 37: 3061-3068. PMID: 25139883, PMCID: PMC4207200, DOI: 10.2337/dc14-0525.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCase-Control StudiesChildCuesEmotionsFemaleFoodHumansLeptinMagnetic Resonance ImagingMaleMotivationPediatric ObesityRewardConceptsLow-calorie foodsBrain responsesFood imagesEmotion processingEmotion responsesAdolescent brainNeural responsesNeural activationHigh-calorie food consumptionFood cravingsNeural alterationsBrain rewardFunctional MRIAdolescent obesityRisk of overconsumptionAdolescentsObesity-related metabolic changesEndogenous leptin levelsFood advertisingMetabolic changesYouthDevelopment of obesityType 2 diabetesLean adolescentsNation's youthBlunted striatal responses to favorite-food cues in smokers
Jastreboff AM, Sinha R, Lacadie CM, Balodis IM, Sherwin R, Potenza MN. Blunted striatal responses to favorite-food cues in smokers. Drug And Alcohol Dependence 2014, 146: 103-106. PMID: 25444233, PMCID: PMC4272899, DOI: 10.1016/j.drugalcdep.2014.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultCase-Control StudiesCerebral CortexCravingCuesFemaleFoodFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleNeostriatumSmokingThalamusYoung AdultConceptsFavorite-food cuesNeural responsesNeutral-relaxing conditionsBody mass indexCue exposureBrain mechanismsRewarding stimuliBrain responsesStriatal responsesCuesDiminished activationLower body mass indexLean body massSmoking cessationMass indexSmoking statusFMRIInsulaSmokersWeight gainStimuliRatingsAudiotapesCaudateBody mass
2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinge-Eating DisorderBrainCuesFemaleHumansInsulinMagnetic Resonance ImagingMaleMiddle AgedObesityStress, PsychologicalConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions
2010
Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study
Jastreboff AM, Potenza MN, Lacadie C, Hong KA, Sherwin RS, Sinha R. Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study. Neuropsychopharmacology 2010, 36: 627-637. PMID: 21048702, PMCID: PMC3055687, DOI: 10.1038/npp.2010.194.Peer-Reviewed Original ResearchConceptsMetabolic factorsFunctional magnetic resonance imagingOB individualsOW/OB individualsVentral striatumVS activationBody mass index statusCortico-limbic regionsNon-homeostatic feedingBody mass indexNormal-weight individualsMagnetic resonance imagingAlcohol cue exposureMass indexObese individualsPlasma glucoseStriatal dysfunctionWeight individualsIndex statusPersonalized stressResonance imagingSignificant associationNW individualsCue exposureMetabolic changes
2007
Three Faces of Hypothalamic Tumors
Jastreboff A, Sherr J. Three Faces of Hypothalamic Tumors. Journal Of Pediatric Endocrinology And Metabolism 2007, 20: 471-472. PMID: 17550209, DOI: 10.1515/jpem.2007.20.4.471.Peer-Reviewed Case Reports and Technical Notes