2016
Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO
Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO. Neuropsychopharmacology 2016, 41: 3042-3050. PMID: 27374277, PMCID: PMC5101552, DOI: 10.1038/npp.2016.115.Peer-Reviewed Original ResearchConceptsBody mass indexVentral striatumObese individualsD2/3R availabilityOB individualsReward regionsSubstantia nigra/ventral tegmental areaDopamine D2/3 receptor availabilityNormal-weight individualsTreatment of obesityVentral tegmental areaNovel pharmacologic targetsD2/3 receptor availabilitySN/VTAAgonist tracersOverweight cohortMass indexWeight individualsTegmental areaBrain reward regionsAntagonist tracersPharmacologic targetReceptor availabilitySecondary analysisNW individualsAltered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
Jastreboff AM, Sinha R, Arora J, Giannini C, Kubat J, Malik S, Van Name MA, Santoro N, Savoye M, Duran EJ, Pierpont B, Cline G, Constable RT, Sherwin RS, Caprio S. Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 2016, 65: 1929-1939. PMID: 27207544, PMCID: PMC5384636, DOI: 10.2337/db15-1216.Peer-Reviewed Original ResearchConceptsObese adolescentsLean adolescentsGlucose ingestionInsulin levelsBrain perfusionBrain regionsSugar-sweetened beverage consumptionAltered brain responsesHedonic brain regionsHippocampal blood flowFurther weight gainFructose ingestionAcyl ghrelinAttenuated suppressionFructose consumptionPerfusion responseBlood flowBrain adaptationBeverage consumptionGreater perfusionPerfusionVentral striatumFunctional MRIWeight gainIngestion
2010
Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study
Jastreboff AM, Potenza MN, Lacadie C, Hong KA, Sherwin RS, Sinha R. Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study. Neuropsychopharmacology 2010, 36: 627-637. PMID: 21048702, PMCID: PMC3055687, DOI: 10.1038/npp.2010.194.Peer-Reviewed Original ResearchConceptsMetabolic factorsFunctional magnetic resonance imagingOB individualsOW/OB individualsVentral striatumVS activationBody mass index statusCortico-limbic regionsNon-homeostatic feedingBody mass indexNormal-weight individualsMagnetic resonance imagingAlcohol cue exposureMass indexObese individualsPlasma glucoseStriatal dysfunctionWeight individualsIndex statusPersonalized stressResonance imagingSignificant associationNW individualsCue exposureMetabolic changes