2000
Novel compounds, ‘1,3-selenazine derivatives’ as specific inhibitors of eukaryotic elongation factor-2 kinase
Cho S, Koketsu M, Ishihara H, Matsushita M, Nairn A, Fukazawa H, Uehara Y. Novel compounds, ‘1,3-selenazine derivatives’ as specific inhibitors of eukaryotic elongation factor-2 kinase. Biochimica Et Biophysica Acta 2000, 1475: 207-215. PMID: 10913818, DOI: 10.1016/s0304-4165(00)00061-1.Peer-Reviewed Original ResearchConceptsV-src-transformed NIH3T3 cellsEukaryotic elongation factor 2 kinaseProtein kinase AElongation factor 2 kinaseProtein kinase CProtein tyrosine kinasesEEF-2KProtein kinaseEEF-2K inhibitorNIH3T3 cellsCalmodulin-dependent protein kinaseV-Src kinaseMultiple protein kinasesCalmodulin-dependent protein kinase IIProtein levelsK inhibitorsProtein kinase IIEEF-2K.Kinase AKinase IITyrosine kinaseKinase CKinaseTs-4Specific inhibitor
1997
The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes EVIDENCE FOR A POTENTIAL ROLE FOR DARPP-32 IN INSULIN ACTION*
Brady M, Nairn A, Saltiel A. The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes EVIDENCE FOR A POTENTIAL ROLE FOR DARPP-32 IN INSULIN ACTION*. Journal Of Biological Chemistry 1997, 272: 29698-29703. PMID: 9368038, DOI: 10.1074/jbc.272.47.29698.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1PP1 activityGlycogen synthasePhosphatase 1DARPP-32Glycogen synthesisPrimary rat adipocytesPP1 proteinProtein DARPP-32Glycogen synthase activityKinetic lagSynthase activityGlycogen accumulationDifferentiationRat adipocytesAdipocytesFibroblast extractsAdipocyte cellsTotal glycogen synthase activitySynthaseInsulin actionPotential roleSpecific activityParticulate fractionInsulin pretreatmentCell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase
Kwon Y, Lee S, Choi Y, Greengard P, Nairn A. Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2168-2173. PMID: 9122166, PMCID: PMC20059, DOI: 10.1073/pnas.94.6.2168.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1PP-1Phosphatase 1Cdc2 kinaseMammalian protein phosphatase 1Cell cycle-dependent phosphorylationCyclin-dependent protein kinase inhibitorEukaryotic cell cycle progressionCell synchronization studiesIntact mammalian cellsNormal cell divisionPP-1 activityCell fractionation studiesState of phosphorylationProtein kinase inhibitorsCell cycle progressionMammalian cellsCell divisionThr-320Cycle progressionMitotic cellsT320NIH 3T3PhosphorylationFractionation studies