Widespread Neuronal Ectopia Associated with Secondary Defects in Cerebrocortical Chondroitin Sulfate Proteoglycans and Basal Lamina in MARCKS-Deficient Mice
Blackshear P, Silver J, Nairn A, Sulik K, Squier M, Stumpo D, Tuttle J. Widespread Neuronal Ectopia Associated with Secondary Defects in Cerebrocortical Chondroitin Sulfate Proteoglycans and Basal Lamina in MARCKS-Deficient Mice. Experimental Neurology 1997, 145: 46-61. PMID: 9184108, DOI: 10.1006/exnr.1997.6475.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBasement MembraneCerebral CortexChondroitin SulfatesFemaleGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsLamininMaleMembrane ProteinsMiceMice, Mutant StrainsMicroscopy, Electron, ScanningMutationMyristoylated Alanine-Rich C Kinase SubstrateNeurogliaNeuronsPia MaterPregnancyProteinsProteoglycansReticulinSynaptophysinConceptsChondroitin sulfate proteoglycanNeuronal ectopiaBasal laminaSulfate proteoglycanProtein kinase CEmbryonic day 13Basal lamina proteinsReticulin stainingSubarachnoid spaceForebrain commissuresPial membraneDay 13EctopiaGross abnormalitiesRetinal laminationMiceMARCKS deficiencyAbnormalitiesPotential mechanismsNeural substratesMarginal zoneProteolytic destructionKinase CProteoglycansLamina