1993
Protein Phosphorylation Regulates the Cellular Trafficking and Processing of the Alzheimer Beta/A4 Amyloid Precursor Protein
Caporaso G, Gandy S, Buxbaum J, Suzuki T, Nordstedt C, Iverfeldt K, Ramabhadran T, Czernik A, Nairn A, Greengard P. Protein Phosphorylation Regulates the Cellular Trafficking and Processing of the Alzheimer Beta/A4 Amyloid Precursor Protein. NATO ASI Series 1993, 201-202. DOI: 10.1007/978-3-662-02928-2_42.Peer-Reviewed Original ResearchAmyloid precursor proteinBeta/A4 amyloid peptideAlzheimer's diseaseBeta/A4 amyloid precursor proteinA4 amyloid precursor proteinAlzheimer beta/A4 amyloid precursor proteinBeta/A4 peptideA4 amyloid peptidePrecursor proteinEarly-onset formAPP metabolismCerebral depositionA4 peptidePC12 cell lineAbnormal processingNeuroendocrine PC12 cell lineDiseaseCellular traffickingCell linesAmyloid peptidesNormal cellular traffickingTransmembrane glycoproteinProteolytic processingProtein phosphorylationPhosphorylation
1990
Nerve Growth Factor‐Induced Down‐Regulation of Calmodulin‐Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP‐Dependent Protein Kinase
Brady M, Nairn A, Wagner J, Palfrey H. Nerve Growth Factor‐Induced Down‐Regulation of Calmodulin‐Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP‐Dependent Protein Kinase. Journal Of Neurochemistry 1990, 54: 1034-1039. PMID: 1689374, DOI: 10.1111/j.1471-4159.1990.tb02354.x.Peer-Reviewed Original ResearchConceptsWild-type cellsCalmodulin-dependent protein kinase IIICAMP-dependent protein kinase activityProtein kinase IIIProtein kinase activityEpidermal growth factorKinase IIIKinase activityA126-1B2 cellsCyclic AMP-dependent protein kinaseAMP-dependent protein kinasePC12 cellsNerve growth factorMutant PC12 cell lineElongation factor 2Growth factorAbility of NGFPC12 cell lineEffects of NGFProtein kinaseNGF additionA126-1B2Down regulationCell linesFactor 2