Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBrainBrain MappingFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingNeural PathwaysPregnancySocial ChangeConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score