WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters*
Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters*. Journal Of Biological Chemistry 2011, 286: 30171-30180. PMID: 21733846, PMCID: PMC3191056, DOI: 10.1074/jbc.m111.222893.Peer-Reviewed Original ResearchConceptsCation-chloride cotransportersSerine-threonine phosphorylationKinase-dependent mannerMammalian brainCell volume regulationSer-383Protein complexesRegulatory cascadeCotransporter regulationXenopus laevis oocytesNovel regulatorWNK2KinaseLaevis oocytesVolume regulationCl accumulationRecognition sitesWNKIntracellular concentrationRegulationSPAKAdult brainThalamic relay cellsThiazide-sensitive NCCMass spectrometry studies