WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability
Kahle KT, Rinehart J, de los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP. WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 16783-16788. PMID: 16275911, PMCID: PMC1283843, DOI: 10.1073/pnas.0508307102.Peer-Reviewed Original ResearchConceptsReticular activating systemCl- influxAltered phosphorylationCerebral cortexResponsive neuronsGABA neurotransmissionNeuronal excitabilityK-Cl cotransporterOpposite effectActivating systemCotransporter NKCC1Intracellular ClCl- effluxNKCC1Surface expressionKCC2Cell volumeExcitabilityNeuronsDownstream targetsWNK3Sensitive kinasesXenopus oocytesIntracellular volumeIon cotransporters