Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size
Bleicken S, Landeta O, Landajuela A, Basañez G, García-Sáez A. Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size. Journal Of Biological Chemistry 2013, 288: 33241-33252. PMID: 24100034, PMCID: PMC3829170, DOI: 10.1074/jbc.m113.512087.Peer-Reviewed Original ResearchConceptsMitochondrial outer membraneApoptotic poreOuter membraneMitochondrial apoptotic factorsSingle vesicle levelActivity of BaxProapoptotic protein BaxProteinaceous channelsVesicle levelMembrane permeabilizationBak proteinForm poresProtein BaxProapoptotic BaxCardiolipin concentrationCytochrome cApoptotic factorsBaxBakPermeabilizationProteinSimilar mechanismMembraneMembrane poresProtein concentration