Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation
Landajuela A, Hervás JH, Antón Z, Montes LR, Gil D, Valle M, Rodriguez JF, Goñi FM, Alonso A. Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation. Biophysical Journal 2016, 110: 411-422. PMID: 26789764, PMCID: PMC4724631, DOI: 10.1016/j.bpj.2015.11.3524.Peer-Reviewed Original ResearchConceptsMembrane fusionCryo-electron microscopy observationsFull membrane fusionNegative intrinsic curvature lipidsCurvature-inducing lipidsImportant catabolic pathwayMultiple fusion eventsAtg8 homologsMembrane tetheringGABARAP proteinsLytic compartmentAP biogenesisGATE-16Fusion eventsIntervesicular mixingCatabolic pathwayMembrane expansionVesicle aggregationMolecular mechanismsLipid geometryVesicle diameterHuman diseasesIntervesicular lipid mixingImportant regulatorLarge vesicles