2024
Sleep Deficiency in Obstructive Sleep Apnea
Adekolu O, Ahsan M, Anwar A, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Sleep Medicine Clinics 2024 DOI: 10.1016/j.jsmc.2024.08.002.Peer-Reviewed Original ResearchNovel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 1-11. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPHypoxic Burden but Not AHI Predicts Risk of Cardiovascular Events: A Secondary Analysis of the RICCADSA Clinical Trial
Peker Y, Zinchuk A, Celik Y, Sands S, Azarbarzin A. Hypoxic Burden but Not AHI Predicts Risk of Cardiovascular Events: A Secondary Analysis of the RICCADSA Clinical Trial. 2024, a4730-a4730. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4730.Peer-Reviewed Original Research0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea
Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.Peer-Reviewed Original ResearchAssociation of cannabis useCannabis useSleep latencyCannabis usersParticipants self-reported cannabis useLong-term cannabis useLong-term effects of cannabisSelf-reported cannabis useHigh prevalence of painObstructive sleep apneaEffects of cannabisPrevalence of painHigher consumption of alcoholProportion of painNo differenceUsers of cannabisSymptoms of painMann-Whitney U testIncreased sleep latencySleep durationRegular alcohol useSlow wave sleepCPAP effectsOSA severityOSA symptomsThe Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review
Chu Y, Zinchuk A. The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 1636. PMID: 38541862, PMCID: PMC10970765, DOI: 10.3390/jcm13061636.Peer-Reviewed Original ResearchObstructive sleep apneaObstructive sleep apnea traitsSleep apneaUpper airway collapseHypoglossal nerve stimulationPositive airway pressureTreatment of patientsImpact treatment responseOral appliancesAirway pressureTreatment responseNerve stimulationTherapy modalitiesClinical useHeterogeneous groupApneaNarrative reviewTherapyPrecision careTreatmentPhysiological factorsPatientsPharmacotherapyClinicModalitiesArousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study
Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.Peer-Reviewed Original ResearchAssociation of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotype0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea
Walker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.Peer-Reviewed Original ResearchObstructive sleep apneaUntreated obstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPsychoactive substance useDaytime symptomsSleep architectureSubstance useSleep characteristicsSleep durationIntroduction Obstructive sleep apneaCaffeine useModerate caffeine useNormal sleep architectureLong-term Efficacy StudyCo-morbid conditionsCurrent cigarette smokersShort sleep durationRecurrent airway obstructionLonger sleep latencyLower sleep durationHeavy alcohol usersObjective sleep characteristicsHeavy alcohol useCross-sectional analysisAirway obstruction0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial
Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.Peer-Reviewed Original ResearchObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPrimary analysisIndividual treatment effectsIntroduction Obstructive sleep apneaSecondary analysisLong-term Efficacy StudyBaseline cognitive scoresBrain age indexBaseline AHIBaseline polysomnogramMulticenter trialRandomized trialsSleep apneaAdherence ratesOSA treatmentTwo-armGroup 2Group 1Efficacy studiesCognitive impairmentCPAPBaseline cognitionMore depressionCognitive scores0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis
Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Zinchuk A, Koo B, Cheungpasitporn W. 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis. Sleep 2023, 46: a384-a384. DOI: 10.1093/sleep/zsad077.0872.Peer-Reviewed Original ResearchPooled risk ratioPeriodic limb movementsRisk ratioSystematic reviewEligible cross-sectional studiesGeneric inverse variance methodLimb movementsStandardized incidence ratiosRisk of hypertensionConfidence intervalsInverse variance methodCross-sectional studyHazard ratioIncidence ratiosHypertension riskInterventional studyOdds ratioRelative riskObservational studyStatistical heterogeneityFunnel plotHypertensionPLMSPublication biasRelevant articlesNicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea
Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.Peer-Reviewed Original ResearchConceptsUntreated obstructive sleep apneaObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudySubstance useDaytime symptomsSleep characteristicsSleep durationCaffeine useModerate caffeine useLong-term Efficacy StudyCurrent cigarette smokersHeavy caffeine usersObjective sleep characteristicsShort sleep durationModerate alcohol useMore REM sleepLower sleep durationHeavy alcohol usersCross-sectional analysisPsychoactive substance useCurrent smokersCurrent smokingComorbid conditionsMedian BMISleep apneaPeriodic limb movements during sleep and risk of hypertension: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, PMCID: PMC10388290, DOI: 10.1016/j.sleep.2023.01.008.Peer-Reviewed Original ResearchConceptsPooled risk ratioPeriodic limb movementsRisk of hypertensionRisk ratioSystematic reviewGeneric inverse variance methodEgger's regression asymmetry testLimb movementsStandardized incidence ratiosConfidence intervalsInverse variance methodHazard ratioIncidence ratiosHypertension riskInterventional studyEligible studiesOdds ratioRelative riskObservational studyStatistical heterogeneityFunnel plotHypertensionPLMSPublication biasRelevant articles
2022
Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness.
Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureObstructive sleep apneaAdverse cardiovascular outcomesPositive airway pressureCardiovascular outcomesAirway pressureCardiovascular benefitsCardiovascular riskSleep apneaExcessive sleepinessEffect of CPAPMultivariable Cox regressionProspective clinical trialsCoronary artery diseaseGreater cardiovascular benefitPulse rate responsesSignificant risk reductionCPAP therapyRepeat revascularizationBaseline polysomnographyCardiovascular mortalityArtery diseasePrimary outcomeCox regressionRespiratory eventsSleep Deficiency in Obstructive Sleep Apnea
Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.Peer-Reviewed Original Research0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)
Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.Peer-Reviewed Original ResearchOutcome expectanciesContinuous positive airway pressureObstructive sleep apneaSub-scale scoresRisk perceptionSelf-efficacy measuresCPAP adherenceIndividual risk perceptionInsomnia Severity Index scoreCPAP therapyEffectiveness of CPAPNon-CPAP therapiesUnstable medical conditionsCo-primary outcomesFirst-line therapyPositive airway pressureApnea-hypopnea indexSeverity Index scoreEpworth Sleepiness ScalePerceptionSex differencesCPAP useOSA severityAirway pressureDaytime symptoms
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsPhysiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapyCardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial
Azarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial. 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.Peer-Reviewed Original ResearchAssociations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes
Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.Peer-Reviewed Original Research