2024
Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeNicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea
Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.Peer-Reviewed Original ResearchConceptsUntreated obstructive sleep apneaObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudySubstance useDaytime symptomsSleep characteristicsSleep durationCaffeine useModerate caffeine useLong-term Efficacy StudyCurrent cigarette smokersHeavy caffeine usersObjective sleep characteristicsShort sleep durationModerate alcohol useMore REM sleepLower sleep durationHeavy alcohol usersCross-sectional analysisPsychoactive substance useCurrent smokersCurrent smokingComorbid conditionsMedian BMISleep apneaPeriodic limb movements during sleep and risk of hypertension: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, PMCID: PMC10388290, DOI: 10.1016/j.sleep.2023.01.008.Peer-Reviewed Original ResearchConceptsPooled risk ratioPeriodic limb movementsRisk of hypertensionRisk ratioSystematic reviewGeneric inverse variance methodEgger's regression asymmetry testLimb movementsStandardized incidence ratiosConfidence intervalsInverse variance methodHazard ratioIncidence ratiosHypertension riskInterventional studyEligible studiesOdds ratioRelative riskObservational studyStatistical heterogeneityFunnel plotHypertensionPLMSPublication biasRelevant articles
2022
Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness.
Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureObstructive sleep apneaAdverse cardiovascular outcomesPositive airway pressureCardiovascular outcomesAirway pressureCardiovascular benefitsCardiovascular riskSleep apneaExcessive sleepinessEffect of CPAPMultivariable Cox regressionProspective clinical trialsCoronary artery diseaseGreater cardiovascular benefitPulse rate responsesSignificant risk reductionCPAP therapyRepeat revascularizationBaseline polysomnographyCardiovascular mortalityArtery diseasePrimary outcomeCox regressionRespiratory eventsSleep Deficiency in Obstructive Sleep Apnea
Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.Peer-Reviewed Original Research
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsPhysiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapy
2020
Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment
Baldassarri SR, Beitel M, Zinchuk A, Redeker NS, Oberleitner DE, Oberleitner LMS, Carrasco D, Madden LM, Lipkind N, Fiellin DA, Bastian LA, Chen K, Yaggi HK, Barry DT. Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment. Sleep And Breathing 2020, 24: 1729-1737. PMID: 32556918, PMCID: PMC7680294, DOI: 10.1007/s11325-020-02123-z.Peer-Reviewed Original ResearchConceptsOpioid use disorderExcessive daytime sleepinessDaytime sleepinessSleep qualityChronic painExcessive daytimeUse disordersConclusionsPoor sleep qualityCurrent chronic painModifiable risk factorsImpaired sleep qualityMultivariable linear regression modelsBody mass indexPoor sleep qualityNon-significant associationMass indexMultivariable analysisPain interferenceRelated comorbiditiesMethadone treatmentClinical correlatesMean PSQIRisk factorsSleep disordersResultsNinety percentUpdate in Sleep in 2019
Leary EB, Zinchuk A, Stone KL, Mehra R. Update in Sleep in 2019. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1473-1479. PMID: 32293912, DOI: 10.1164/rccm.202003-0586up.BooksPhysiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke
Zinchuk AV, Redeker NS, Chu JH, Liang J, Stepnowsky C, Brandt CA, Bravata DM, Wellman A, Sands SA, Yaggi HK. Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1568-1572. PMID: 32083949, PMCID: PMC7301748, DOI: 10.1164/rccm.201911-2203le.Peer-Reviewed Original Research
2019
Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine
Zinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.BooksConceptsPhenotypic subtypesImpact of CPAPManagement of OSAApnea-hypopnea indexHealth-related qualitySeverity of OSASubtypes of patientsPrecision medicineSymptom-based subtypesPhenotype reproducibilitySleep apneaClinical manifestationsPathophysiological causesDisturbed sleepRisk factorsCardiovascular diseaseTreatment approachesPatient's lifeRelevant outcomesPersonalized approachCPAPSubtypesOSAPotential rolePatientsSleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep Medicine
Zinchuk A, Yaggi HK. Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep Medicine. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 412-413. PMID: 30916985, PMCID: PMC6701039, DOI: 10.1164/rccm.201903-0545ed.Peer-Reviewed Case Reports and Technical Notes
2018
Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea.
Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.Peer-Reviewed Original ResearchConceptsLong-term CPAP useObstructive sleep apneaLow respiratory arousal thresholdLow ArTHRespiratory arousal thresholdCPAP useNonobese patientsClinical featuresSleep apneaOdds ratioArousal thresholdContinuous positive airway pressure usePositive airway pressure usePhysiologic phenotypeRegular CPAP useAntihypertensive medication useBody mass indexAssociated clinical featuresUnited States veteransAntihypertensive medicationsPolysomnography characteristicsClinical characteristicsCPAP adherenceAntidepressant useMedication useA Young Man With Hemoptysis and Cavitary Lung Lesions
Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.Peer-Reviewed Case Reports and Technical NotesConceptsBacillus Calmette-Guérin (BCG) vaccineCavitary lung lesionsPrior cigarette smokingCalmette-Guérin vaccineHistory of alcoholIntermittent hemoptysisNight sweatsCigarette smokingMusculoskeletal symptomsLung lesionsMild fatigueDrug useWeight lossHemoptysisYoung menMenDyspneaRashMedicationsSmokingFeverVaccineLesionsSymptomsMonths
2017
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome
2016
Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches
Zinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches. Sleep Medicine Reviews 2016, 35: 113-123. PMID: 27815038, PMCID: PMC5389934, DOI: 10.1016/j.smrv.2016.10.002.BooksConceptsObstructive sleep apneaOSA phenotypesSleep apneaPathophysiologic risk factorsApnea-hypopnea indexCategory of patientsHypopnea indexClinical featuresPatient selectionRisk factorsClinical trialsClinical phenotypingDisease featuresSignificant prognosticPersonalized treatmentHeterogeneous disorderClinical validationTherapeutic categoriesTreatment implicationsUnderstanding of mechanismsMeaningful outcomesApneaPatientsPhenotypeLack associationThe Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delay
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control
2010
Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue
Zinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, McCullough LD. Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue. BMC Medical Education 2010, 10: 49. PMID: 20573257, PMCID: PMC2900283, DOI: 10.1186/1472-6920-10-49.Peer-Reviewed Original ResearchConceptsMedical studentsBedside tutorialsFourth-year medical studentsEffective educational experienceYear medical studentsComplexity of neuroanatomyConfidence of traineesInternal medicine residency programsNeurology teachingEducational experienceInsufficient teachingUS schoolsNeurology educationClinical yearsMedicine residency programsTeachingStudentsUS universitiesMedical traineesMedical specialtiesConclusionsMedical studentsLeast confidenceResidency programsUniversityUS trainees