2023
Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexChronotypeContinuous Positive Airway PressureFemaleHumansMalePatient ComplianceSleepSleep Apnea, ObstructiveConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotype
2022
Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness.
Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedContinuous Positive Airway PressureCoronary Artery DiseaseDisorders of Excessive SomnolenceFemaleHumansMaleMiddle AgedProspective StudiesSleep Apnea, ObstructiveSleepinessTreatment OutcomeConceptsContinuous positive airway pressureObstructive sleep apneaAdverse cardiovascular outcomesPositive airway pressureCardiovascular outcomesAirway pressureCardiovascular benefitsCardiovascular riskSleep apneaExcessive sleepinessEffect of CPAPMultivariable Cox regressionProspective clinical trialsCoronary artery diseaseGreater cardiovascular benefitPulse rate responsesSignificant risk reductionCPAP therapyRepeat revascularizationBaseline polysomnographyCardiovascular mortalityArtery diseasePrimary outcomeCox regressionRespiratory events
2021
Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedContinuous Positive Airway PressureCoronary Artery DiseaseFemaleFollow-Up StudiesHumansLinear ModelsMaleMiddle AgedPatient CompliancePolysomnographySleep Apnea, ObstructiveConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapy
2020
Update in Sleep in 2019
Leary EB, Zinchuk A, Stone KL, Mehra R. Update in Sleep in 2019. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1473-1479. PMID: 32293912, DOI: 10.1164/rccm.202003-0586up.BooksPhysiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke
Zinchuk AV, Redeker NS, Chu JH, Liang J, Stepnowsky C, Brandt CA, Bravata DM, Wellman A, Sands SA, Yaggi HK. Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1568-1572. PMID: 32083949, PMCID: PMC7301748, DOI: 10.1164/rccm.201911-2203le.Peer-Reviewed Original Research
2019
Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine
Zinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.BooksMeSH KeywordsAnthropometryArousalCardiovascular DiseasesCluster AnalysisContinuous Positive Airway PressureHumansHypoxiaPhenotypePolysomnographyPrecision MedicineQuality of LifeRisk FactorsSleep Apnea, ObstructiveSleepinessConceptsPhenotypic subtypesImpact of CPAPManagement of OSAApnea-hypopnea indexHealth-related qualitySeverity of OSASubtypes of patientsPrecision medicineSymptom-based subtypesPhenotype reproducibilitySleep apneaClinical manifestationsPathophysiological causesDisturbed sleepRisk factorsCardiovascular diseaseTreatment approachesPatient's lifeRelevant outcomesPersonalized approachCPAPSubtypesOSAPotential rolePatients
2018
Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea.
Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.Peer-Reviewed Original ResearchMeSH KeywordsArousalContinuous Positive Airway PressureCross-Sectional StudiesHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedPatient CompliancePolysomnographyPrevalenceRespirationSleep Apnea, ObstructiveUnited StatesVeteransConceptsLong-term CPAP useObstructive sleep apneaLow respiratory arousal thresholdLow ArTHRespiratory arousal thresholdCPAP useNonobese patientsClinical featuresSleep apneaOdds ratioArousal thresholdContinuous positive airway pressure usePositive airway pressure usePhysiologic phenotypeRegular CPAP useAntihypertensive medication useBody mass indexAssociated clinical featuresUnited States veteransAntihypertensive medicationsPolysomnography characteristicsClinical characteristicsCPAP adherenceAntidepressant useMedication use