2024
Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis
Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Zinchuk A, Koo B, Cheungpasitporn W. 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis. Sleep 2023, 46: a384-a384. DOI: 10.1093/sleep/zsad077.0872.Peer-Reviewed Original ResearchPooled risk ratioPeriodic limb movementsRisk ratioSystematic reviewEligible cross-sectional studiesGeneric inverse variance methodLimb movementsStandardized incidence ratiosRisk of hypertensionConfidence intervalsInverse variance methodCross-sectional studyHazard ratioIncidence ratiosHypertension riskInterventional studyOdds ratioRelative riskObservational studyStatistical heterogeneityFunnel plotHypertensionPLMSPublication biasRelevant articlesPeriodic limb movements during sleep and risk of hypertension: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, PMCID: PMC10388290, DOI: 10.1016/j.sleep.2023.01.008.Peer-Reviewed Original ResearchConceptsPooled risk ratioPeriodic limb movementsRisk of hypertensionRisk ratioSystematic reviewGeneric inverse variance methodEgger's regression asymmetry testLimb movementsStandardized incidence ratiosConfidence intervalsInverse variance methodHazard ratioIncidence ratiosHypertension riskInterventional studyEligible studiesOdds ratioRelative riskObservational studyStatistical heterogeneityFunnel plotHypertensionPLMSPublication biasRelevant articles
2022
Sleep Deficiency in Obstructive Sleep Apnea
Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.Peer-Reviewed Original Research
2017
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome