2022
Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness.
Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureObstructive sleep apneaAdverse cardiovascular outcomesPositive airway pressureCardiovascular outcomesAirway pressureCardiovascular benefitsCardiovascular riskSleep apneaExcessive sleepinessEffect of CPAPMultivariable Cox regressionProspective clinical trialsCoronary artery diseaseGreater cardiovascular benefitPulse rate responsesSignificant risk reductionCPAP therapyRepeat revascularizationBaseline polysomnographyCardiovascular mortalityArtery diseasePrimary outcomeCox regressionRespiratory events
2017
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome