2019
Counting Calories: The Cost of Inflammation
Wang A, Medzhitov R. Counting Calories: The Cost of Inflammation. Cell 2019, 177: 223-224. PMID: 30951664, DOI: 10.1016/j.cell.2019.03.022.Peer-Reviewed Original ResearchAn evolutionary perspective on immunometabolism
Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science 2019, 363 PMID: 30630899, PMCID: PMC6892590, DOI: 10.1126/science.aar3932.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionCell DifferentiationCell ProliferationEnergy MetabolismHumansHypothalamusImmune SystemImmune ToleranceConceptsMetabolic programsBiological functionsCell fate decisionsLife history theoryDifferent biological functionsDistinct metabolic programsOrganismal physiologyFate decisionsField of immunometabolismAnabolic metabolismCell quiescenceBiological processesHistory theoryEvolutionary perspectiveEcological principlesCatabolic metabolismDe novoBiological infrastructureMetabolismImmunometabolismRecent studiesDifferentiationPhysiologyNovoNutrients
2018
Glucose metabolism mediates disease tolerance in cerebral malaria
Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 11042-11047. PMID: 30291189, PMCID: PMC6205430, DOI: 10.1073/pnas.1806376115.Peer-Reviewed Original ResearchConceptsCerebral malariaGlucose metabolismBlood-brain barrier permeabilityAlternative fuel substrateCerebral malaria modelInflammation-induced anorexiaParasitic disease malariaVehicle-treated animalsAcute inflammatory conditionsTissue-protective mechanismsPotential therapeutic targetDifferent inflammatory statesInhibition of glycolysisViral inflammationANKA infectionThrombotic complicationsInfectious inflammationInflammatory stateBacterial inflammationImmune infiltrationInflammatory conditionsInflammatory diseasesMale miceBarrier permeabilitySickness behavior