2010
Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis & Rheumatism 2010, 62: 3436-3446. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus nephritisSLE patientsCXCR4 expressionPeripheral blood leukocytesNeuropsychiatric SLEB cellsLupus erythematosusBlood leukocytesSLE Disease Activity Index (SLEDAI) scoreClasses of LNDisease activity index scoreSeverity of LNNeuropsychiatric systemic lupus erythematosusCentral nervous system involvementClass IV lupus nephritisActive neuropsychiatric systemic lupus erythematosusCXCR4/CXCL12 axisAnti-CXCL12 antibodyActivity index scoreNervous system involvementSubset of patientsMurine lupus modelsGlomeruli of kidneysPotential therapeutic target
2009
Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic Autoimmunity
Wang A, Mohan C, Wakeland E. Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic Autoimmunity. 2009, 737-748. DOI: 10.1016/b978-0-12-449851-8.00044-9.Peer-Reviewed Original ResearchLupus nephritisImmune complexesClass V lupus nephritisSystemic lupus erythematosus diseaseMembranous proliferative glomerulonephritisSevere kidney pathologyWhite SLE patientsContinuum of diseaseGlomerular capillary wallPathogenic autoimmunityRenal insufficiencySLE patientsKidney diseaseSerum concentrationsProliferative glomerulonephritisSystemic autoimmunityDisease progressionChronic diseasesKidney pathologyGlomerular scarringNephritisSLE susceptibilityRole of geneticsClass IIIC1q component