CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus
Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus. The Journal Of Immunology 2009, 182: 4448-4458. PMID: 19299746, PMCID: PMC2946082, DOI: 10.4049/jimmunol.0801920.Peer-Reviewed Original ResearchConceptsMurine modelIncreased CXCR4 expressionPathogenesis of lupusB cell subsetsPromising therapeutic targetCXCR4/CXCL12Multiple murine modelsB cell survivalLupus nephritisActive nephritisSerum autoantibodiesCell subsetsCXCR4 expressionInflammatory cytokinesNephritic kidneysOrgan diseasePathogenic rolePlasma cellsLeukocyte traffickingTherapeutic targetLupusPeptide antagonistCXCR4Surface moleculesNephritis